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Pharmacokinetics of Nivolumab and Erythropoietin in a Rat Model of Diet-Induced Obesity.
Pharm Res
January 2025
Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ, 08854, USA.
Purpose: To investigate how obesity affects the pharmacokinetics of biologics in a rat model.
Method: Male Long-Evans rats were fed a high-fat diet from the age of 3 weeks and development of obesity was monitored by measuring body size and composition (fat and lean mass). The animals received nivolumab (1 and 8 mg/kg) or recombinant human erythropoietin (rHuEPO, 1000 IU/kg) by intravenous or subcutaneous injection.
Background: Uncertainty about optimal tranexamic acid (TXA) dosage has led to significant practice variation in hip arthroplasty. We aimed to identify the optimal i.v.
View Article and Find Full Text PDFQuality of life and return to work rates in the first two years following major burn injury.
Burns
December 2024
School of Public Health and Preventive Medicine, Monash University, Australia; Population Data Science, Swansea University, Wales.
Background: A better understanding of how major burns patients recover following injury is vital in assessing trauma care and informing healthcare and rehabilitation provision. We aimed to describe the longer-term health and return to work status of major burns patients and identify factors associated with positive outcomes i.e.
View Article and Find Full Text PDFImpact of Total Body Surface Area Burn Injuries on Clinical Outcomes and Comorbidities in Elderly Patients Aged Over 65.
Cureus
December 2024
Plastic and Reconstructive Surgery, Marshall University Joan C. Edwards School of Medicine, Huntington, USA.
Introduction: Burn injuries are associated with high mortality and morbidity, especially in the elderly population. Although burns are preventable, they account for the fourth most common cause of trauma worldwide. The majority of the mortality associated with burn victims is also seen in the elderly age group.
View Article and Find Full Text PDFAssociation between phase angle and daily creatinine excretion changes in critically ill patients: an approach to muscle mass.
Front Physiol
January 2025
Departamento de Paciente Crítico, Clínica Alemana de Santiago, Santiago, Chile.
Assessing muscle mass in critically ill patients remains challenging. This retrospective cohort study explores the potential of phase angle (PA°) derived from bioelectrical impedance analysis (BIA) as a surrogate marker for muscle mass monitoring by associating it with daily creatinine excretion (DCE), a structural and metabolic muscle mass marker. In 20 ICU patients, we observed a linear relationship between PA° and DCE at initial (S1) and follow-up (S2) points, with Rho values of 0.
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