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First measurements of radon-220 diffusion in mice tumors, towards treatment planning in diffusing alpha-emitters radiation therapy.
Med Phys
July 2024
Unit of Nuclear Engineering, Faculty of Engineering Sciences, Ben-Gurion University of the Negev, Beersheba, Israel.
Background: Diffusing alpha-emitters radiation therapy ("Alpha-DaRT") is a new method for treating solid tumors with alpha particles, relying on the release of the short-lived alpha-emitting daughter atoms of radium-224 from interstitial sources inserted into the tumor. Alpha-DaRT tumor dosimetry is governed by the spread of radium's progeny around the source, as described by an approximate framework called the "diffusion-leakage model". The most important model parameters are the diffusion lengths of radon-220 and lead-212, and their estimation is therefore essential for treatment planning.
View Article and Find Full Text PDFTracing the Evolution of Prostate Brachytherapy in the 20th Century.
Oncology
March 2024
Department of Radiation Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, Québec, Canada.
Background: Prostate brachytherapy (BT) techniques have evolved over the past century. This paper aimed to preserve our collective memory of history and the early development of its technique. We searched articles in PubMed and Google Scholar using keywords referring to authors, dates, and BT technical details, including different radioactive sources and country-specific publications.
View Article and Find Full Text PDFNovel and Fusion Genes in T-cell Acute Lymphoblastic Leukemia.
Cancer Genomics Proteomics
January 2023
Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Background/aim: T-cell acute lymphoblastic leukemia (T-ALL) is a rare malignancy characterized by proliferation of early T-cell precursors that replace normal hematopoietic cells. T-ALL cells carry non-random chromosome aberrations, fusion genes, and gene mutations, often of prognostic significance. We herein report the genetic findings in cells from a T-ALL patient.
View Article and Find Full Text PDFFusion of High Mobility Group AT-hook 2 Gene () With the Chromosome 12 Open Reading Frame 42 Gene () in an Aggressive Angiomyxoma With del(12)(q14q23) as the Sole Cytogenetic Anomaly.
Cancer Genomics Proteomics
August 2022
Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Background/aim: Aggressive angiomyxomas are mostly found in the pelvic and perineal region and are prone to recur after surgery. Cytogenetic information is available on only nine such tumors. Herein, we report the cytogenetic anomaly and its molecular consequence in another aggressive angiomyxoma.
View Article and Find Full Text PDFFibrinogen-like protein 2 in gastrointestinal stromal tumour.
J Cell Mol Med
February 2022
Laboratory of Molecular Oncology, Department of Oncology, University of Helsinki, Helsinki, Finland.
Gastrointestinal stromal tumour (GIST), the most common sarcoma of the gastrointestinal tract, can be treated effectively with tyrosine kinase inhibitors, such as imatinib. Cancer immune therapy has limited efficacy, and little is known about the immune suppressive factors in GISTs. Fibrinogen-like protein 2 (FGL2) is expressed either as a membrane-associated protein or as a secreted soluble protein that has immune suppressive functions.
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