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Riverine antibiotic resistome along an anthropogenic gradient.
Front Microbiol
February 2025
Department of Technical Biogeochemistry, Helmholtz Centre for Environmental Research, Leipzig, Germany.
The introduction of antibiotic-resistant bacteria into riverine systems through the discharge of wastewater treatment plant (WWTP) effluent and agricultural waste poses significant health risks. Even when not pathogenic, these bacteria can act as reservoirs for antibiotic resistance genes (ARGs), transferring them to pathogens that infect humans and animals. In this study, we used fluorescence hybridization, qPCR, and metagenomics to investigate how anthropogenic activities affect microbial abundance and the resistome along the Holtemme River, a small river in Germany, from near-pristine to human-impacted sites.
View Article and Find Full Text PDFSynergistic antibacterial effects of pinaverium bromide and oxacillin against .
Zhong Nan Da Xue Xue Bao Yi Xue Ban
October 2024
Department of Laboratory Medicine, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Objectives: () adheres to the surface of medical devices, forming highly drug-resistant biofilms, which has made the development of novel antibacterial agents against and its biofilms a key research focus. By drug repurposing, this study aims to explore the combinational antimicrobial effects between pinaverium bromide (PVB), a -type calcium channel blocker, and oxacillin (OXA) against .
Methods: Clinical isolates of were collected from January to September 2022 at the Department of Clinical Laboratory of the Third Xiangya Hospital, Central South University.
Molecular and genomic investigation unveils Pseudomonas putida as an emerging multidrug-resistant pathogen linked to bovine clinical mastitis.
Microb Pathog
March 2025
Molecular Biology and Bioinformatics Laboratory, Department of Gynecology, Obstetrics and Reproductive Health, Gazipur Agricultural University, Gazipur, 1706, Bangladesh. Electronic address:
Pseudomonas putida is one of the emerging pathogens responsible causing mastitis in lactating animals. This study investigated the prevalence, antimicrobial resistance (AMR), genetic diversity and virulence factor genes (VFGs) to highlight the pathogenic potentials of P. putida strains isolated from milk, feces and farm soil of dairy cows diagnosed with clinical mastitis (CM).
View Article and Find Full Text PDFFast and Accurate Prediction of Antibiotic Susceptibility in Clinical Methicillin-Resistant Isolates Using ATR-FTIR Spectroscopy: A Model Validation Study.
Anal Chem
March 2025
Infection Program, Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
Diagnosing antimicrobial resistance (AMR) remains critical for improving patient survival rates and treatment outcomes. Current antibiotic susceptibility tests (AST) suffer prolonged turnaround times, necessitating a minimum of 24 h for results. Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy emerges as a promising phenotypic testing method in bacteriology due to its rapid chemical characterization capability.
View Article and Find Full Text PDFClinical presentation, treatment, and antimicrobial susceptibility of 155 sequential infections.
Microbiol Spectr
March 2025
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Unlabelled: is known to be virulent, but there are few large-scale epidemiologic studies of this species to define types of infection, susceptibility patterns, and severity. isolates from any culture at four U.S.
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