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Feasibility of implementing a rapid-learning methodology to inform radiotherapy treatments: key professional stakeholders' views.
BMJ Oncol
March 2024
Manchester Centre for Health Psychology, Division of Psychology and Mental Health, School of Health Sciences, The University of Manchester, Manchester, UK.
Objective: Pragmatic methodologies, often termed rapid-learning, are being pursued that can match the pace of innovation in radiotherapy and generate evidence from the real-world treatment setting. It is important to understand the feasibility of implementing such pragmatic approaches before their application in practice. This study investigated key professional stakeholders' perceptions and opinions of rapid-learning and real-world data (RWD).
View Article and Find Full Text PDFSingle cell RNA sequencing improves the next generation of approaches to AML treatment: challenges and perspectives.
Mol Med
January 2025
Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 8174673461, Iran.
Acute myeloid leukemia (AML) is caused by altered maturation and differentiation of myeloid blasts, as well as transcriptional/epigenetic alterations, all leading to excessive proliferation of malignant blood cells in the bone marrow. Tumor heterogeneity due to the acquisition of new somatic alterations leads to a high rate of resistance to current therapies or reduces the efficacy of hematopoietic stem cell transplantation (HSCT), thus increasing the risk of relapse and mortality. Single-cell RNA sequencing (scRNA-seq) will enable the classification of AML and guide treatment approaches by profiling patients with different facets of the same disease, stratifying risk, and identifying new potential therapeutic targets at the time of diagnosis or after treatment.
View Article and Find Full Text PDFCommon Oncologic Wounds.
Nurs Clin North Am
March 2025
Conway School of Nursing, The Catholic University of America, Washington, DC, USA; Inova Health System, Falls Church, VA, USA. Electronic address:
This article presents clinically focused, evidence-based summary of common wounds and alterations in tissue/skin associated with oncologic treatment, with a focus on risk factors, identification, prevention, and management of acute radiation dermatitis and chemotherapy-induced extravasation.
View Article and Find Full Text PDFSignificant Radiation Reduction Using Cloud-Based AI Imaging in Manually Matched Cohort of Complex Aneurysm Repair.
Ann Vasc Surg
January 2025
Division of Vascular & Endovascular Surgery, Weill Cornell Medicine, New York, NY. Electronic address:
Objective: Cloud-based, surgical augmented intelligence (Cydar Medical, Cambridge, UK) can be used for surgical planning and intraoperative imaging guidance during complex endovascular aortic procedures. We aim to evaluate radiation exposure, operative safety metrics, and post-operative renal outcomes following implementation of Cydar imaging guidance using a manually matched cohort of aortic procedures.
Methods: We retrospectively reviewed our prospectively maintained database of endovascular aortic cases.
Normal tissue complication probability model predicting taste impairment in head and neck cancer patients: Evaluating the taste bud bearing tongue mucosa as a predictor.
Radiother Oncol
January 2025
Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Electronic address:
Background/purpose: Taste impairment is a common yet complex toxicity of head and neck cancer (HNC) radiotherapy treatment that may affect quality of life of survivors. This study aimed to predict acute and late taste impairment using taste bud bearing tongue mucosa as a new taste-specific organ-at-risk compared to full oral cavity as identified in previous studies.
Materials/methods: Included HNC patients were treated with curative radiotherapy between 2007 and 2022.
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