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Engaging dystonia networks with subthalamic stimulation.
Proc Natl Acad Sci U S A
January 2025
Center for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115.
Deep brain stimulation is an efficacious treatment for dystonia. While the internal pallidum serves as the primary target, recently, stimulation of the subthalamic nucleus (STN) has been investigated. However, optimal targeting within this structure and its surroundings have not been studied in depth.
View Article and Find Full Text PDFHigh-Performance Porous Supports Based on Hydroxyl-Terminated Polysulfone and CO/CO-Selective Composite Membranes.
Polymers (Basel)
December 2024
Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1, 119991 Moscow, Russia.
The scope of this work was to develop a thin-film composite (TFC) membrane for the separation of CO/CO mixtures, which are relevant for many processes of gas processing and gasification of carbon-based feedstock. Special attention was given to the development of highly permeable porous polysulfone (PSF) supports (more than 26,000 GPU for CO) since both the selective and support layers contribute significantly to the overall performance of the TFC membrane. The PSF porous support is widely used in commercial and lab-scale TFC membranes, and its porous structure and other exploitation parameters are set during the non-solvent-induced phase separation (NIPS) process.
View Article and Find Full Text PDFEncompassing view of spatial and single-cell RNA sequencing renews the role of the microvasculature in human atherosclerosis.
Nat Cardiovasc Res
January 2025
Department of Medicine 2, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Atherosclerosis is a pervasive contributor to ischemic heart disease and stroke. Despite the advance of lipid-lowering therapies and anti-hypertensive agents, the residual risk of an atherosclerotic event remains high, and developing therapeutic strategies has proven challenging. This is due to the complexity of atherosclerosis with a spatial interplay of multiple cell types within the vascular wall.
View Article and Find Full Text PDFStrategies to Address Racial and Ethnic Disparities in Health and Health Care for Chronic Conditions : An Evidence Map of Research From 2017 to 2024.
Ann Intern Med
December 2024
Division of Health Policy & Management, School of Public Health, University of Minnesota, Minneapolis, Minnesota (T.L., H.I.A., K.B., R.P., K.C., A.M.C., J.D., S.W.G., L.H., R.J., M.N., M.B.).
Background: Racial and ethnic disparities in health and health care persist in the United States, adversely affecting outcomes in prevention and treatment of chronic conditions among adults.
Purpose: To map interventions aimed at reducing racial and ethnic disparities and improving health outcomes in the prevention and treatment of chronic conditions in adults.
Data Sources: Searches of MEDLINE, CINAHL, and Scopus from January 2017 to April 2024, supplemented with gray literature.
Cardiac Reprogramming and Gata4 Overexpression Reduce Fibrosis and Improve Diastolic Dysfunction in Heart Failure With Preserved Ejection Fraction.
Circulation
December 2024
Department of Cardiology, Keio University School of Medicine, Tokyo, Japan. (T.S., M.N., T.M., M.I.).
Background: Heart failure with preserved ejection fraction (HFpEF) is a major health concern. Pathological stimuli and interactions between cardiac fibroblasts (CFs) and other cell types may lead to cardiac fibrosis and diastolic dysfunction, which are hallmarks of HFpEF. Interstitial and perivascular cardiac fibrosis correlates with poor prognosis in HFpEF; however, mechanisms of fibrosis remain poorly elucidated, and targeted therapies are lacking.
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