Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Roles of Transcription Factors in the Development and Reprogramming of the Dopaminergic Neurons.
Int J Mol Sci
January 2022
Center for Clinical Research on Neurological Diseases, First Affiliated Hospital, Dalian Medical University, Dalian 116021, China.
The meso-diencephalic dopaminergic (mdDA) neurons regulate various critical processes in the mammalian nervous system, including voluntary movement and a wide range of behaviors such as mood, reward, addiction, and stress. mdDA neuronal loss is linked with one of the most prominent human movement neurological disorders, Parkinson's disease (PD). How these cells die and regenerate are two of the most hotly debated PD research topics.
View Article and Find Full Text PDFDescending Dopaminergic Inputs to Reticulospinal Neurons Promote Locomotor Movements.
J Neurosci
October 2020
Department of Neuroscience, Université de Montréal, Montréal, Québec H3C 3J7, Canada
Meso-diencephalic dopaminergic neurons are known to modulate locomotor behaviors through their ascending projections to the basal ganglia, which in turn project to the mesencephalic locomotor region, known to control locomotion in vertebrates. In addition to their ascending projections, dopaminergic neurons were found to increase locomotor movements through direct descending projections to the mesencephalic locomotor region and spinal cord. Intriguingly, fibers expressing tyrosine hydroxylase (TH), the rate-limiting enzyme of dopamine synthesis, were also observed around reticulospinal neurons of lampreys.
View Article and Find Full Text PDFWhy acute unilateral vestibular midbrain lesions rarely manifest with rotational vertigo: a clinical and modelling approach to head direction cell function.
J Neurol
May 2018
German Center for Vertigo and Balance Disorders, Ludwig-Maximilians Universität, Munich, Germany.
A retrospective clinical study focused on the frequency of rotational vertigo in 63 patients with acute unilateral midbrain strokes involving the vestibular and ocular motor systems. In contrast to unilateral pontomedullary brainstem lesions, rotational vertigo in midbrain lesions occurred with a low frequency (14%) and transient (< 1 day) course. Swaying vertigo or unspecific dizziness (22%) and postural imbalance (31%) were more frequent.
View Article and Find Full Text PDFCytomegalovirus Infection: The Neurodevelopmental Peptide Signatures.
Curr Drug Discov Technol
August 2019
Department of Biosciences, Biotechnologies & Biopharmaceutics, University of Bari, Bari, Italy.
Background And Objective: HCMV infection may cause neurodevelopmental disorders, including intellectual disability, hearing loss, cortical malformations, and calcifications. Theorizing about the still unknown molecular basis of HCMV-related diseases, this study analyzes the peptide sharing between HCMV, strains AD169 and Merlin, and human proteins, searching for shared sequences that might lead to crossreactive autoimmune injuries in the brain during immune responses following HCMV infection.
Method: HCMV proteins were analyzed for peptides shared with the human proteome using the Pir Peptide Match resource.
Right-sided dominance of the bilateral vestibular system in the upper brainstem and thalamus.
J Neurol
October 2017
Graduate School of Systemic Neuroscience, Ludwig-Maximilian University Munich, Munich, Germany.
MRI diffusion tensor imaging tractography was performed on the bilateral vestibular brainstem pathways, which run from the vestibular nuclei via the paramedian and posterolateral thalamic subnuclei to the parieto-insular vestibular cortex. Twenty-one right-handed healthy subjects participated. Quantitative analysis revealed a rope-ladder-like system of vestibular pathways in the brainstem with crossings at pontine and mesencephalic levels.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!