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Rhinoviruses and respiratory enteroviruses remain among the leading causes of acute respiratory infections, particularly in children. Little is known about the genetic diversity of enteroviruses and rhinoviruses in pediatric patients with acute respiratory infections in Russia. We assessed the prevalence of human rhinoviruses/enteroviruses (HRV/EV) in 1992 children aged 0 to 17 years hospitalized with acute respiratory infections during the 2023-2024 epidemic season using PCR.
View Article and Find Full Text PDFActa Paediatr
December 2024
Department of Paediatrics and Adolescent Medicine, Danish PCD & Child Centre, CF Centre Copenhagen, Paediatric Pulmonary Service, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Aim: Knowledge about the clinical role that respiratory viruses play in infants and toddlers with cystic fibrosis (CF) remains limited. We determined the prevalence of respiratory viruses in routine respiratory secretion samples in children aged 0-3 years with CF. Associations with bacterial infections, respiratory tract symptoms and lung function were also explored.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, China.
After ending the three-year zero COVID policy in China, the epidemiology of other respiratory pathogens has been affected. This study aimed to characterize of common respiratory pathogen infections in pediatric patients hospitalized for acute respiratory tract infections (ARTIs) in Suzhou before and after ending the zero COVID policy. Nasopharyngeal aspirates (NPAs) were obtained from children with ARTIs (aged ≤ 16 years) at the Children's Hospital of Soochow University for the detection of respiratory syncytial virus (RSV), influenza A (FluA), FluB, human parainfluenza virus (HPIV), adenovirus (ADV), human rhinovirus (HRV), bocavirus (BoV), human metapneumovirus (HMPV), and mycoplasma pneumoniae (MP).
View Article and Find Full Text PDFNat Commun
December 2024
Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
The lack of a robust system to reproducibly propagate HRV-C, a family of viruses refractory to cultivation in standard cell lines, has substantially hindered our understanding of this common respiratory pathogen. We sought to develop an organoid-based system to reproducibly propagate HRV-C, and characterize virus-host interaction using respiratory organoids. We demonstrate that airway organoids sustain serial virus passage with the aid of CYT387-mediated immunosuppression, whereas nasal organoids that more closely simulate the upper airway achieve this without any intervention.
View Article and Find Full Text PDFTuberc Respir Dis (Seoul)
December 2024
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Background: Respiratory infection is a major cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). We investigated the presence of bacterial and viral pathogens and clinical features in patients with AECOPD.
Methods: This retrospective study included 1,186 patients diagnosed with AECOPD from 28 hospitals in South Korea between 2015-2018.
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