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Management of Muscle Cramps in Patients With Cirrhosis: A Systematic Review of Randomised Controlled Trials.
Aliment Pharmacol Ther
January 2025
Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia.
Background: Muscle cramps are common in patients with cirrhosis. Despite their prevalence and impact on health-related quality of life, there are no widely used clinical practice guidelines for management of muscle cramps in cirrhosis. The aim of this review was to critically evaluate current evidence regarding treatment of muscle cramps in cirrhosis.
View Article and Find Full Text PDFCorrespondence on 'Methocarbamol versus diazepam in acute low back pain in the emergency department: a randomised double-blind clinical trial' by Sharifi .
Emerg Med J
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Commentary: Is Polyethylene Glycol Toxicity From Intravenous Methocarbamol Fact or Fiction?
J Pain Palliat Care Pharmacother
June 2024
Department of Pharmacy: Clinical and Administrative Sciences, The University of Oklahoma College of Pharmacy, Oklahoma City, OK, USA.
Methocarbamol is an antispasmodic muscle relaxant and was the fourth most-prescribed muscle relaxant by volume in the United States in 2021. Intravenous (IV) methocarbamol contains the excipient, polyethylene glycol (PEG), which has been implicated in metabolic acidosis and nephrotoxicity. Intravenous methocarbamol was first approved by the US Food and Drug Administration in 1959 and at that time the IV methocarbamol prescribing information warned of PEG-associated adverse drug events in patients living with renal impairment; however, the manufacturer acknowledged data were lacking to objectively support this claim.
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