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HMGA2 Expression Predicts Subtype, Survival, and Treatment Outcome in Pancreatic Ductal Adenocarcinoma.
Clin Cancer Res
December 2024
Fred Hutchinson Cancer Center, Seattle, WA, United States.
Purpose: To establish HMGA2 as a marker of basal-like disease in pancreatic ductal adenocarcinoma (PDAC) and explore its use as a biomarker for prognosis and treatment resistance.
Experimental Design: We identified high expression of HMGA2 in basal PDAC cells in a scRNAseq Atlas of 172 patient samples. We then analyzed HMGA2 expression, along with expression of the classical marker GATA6, in a cohort of 580 PDAC samples with multiplex immunohistochemistry.
Secondary intestinal amyloidosis visualized on a scintigraphy with [Tc]Tc-HMDP.
Rev Esp Med Nucl Imagen Mol (Engl Ed)
October 2024
Servicio de Medicina Nuclear - PET (ICS - IDI), Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
Embryonic macrophages support endocrine commitment during human pancreatic differentiation.
Cell Stem Cell
November 2024
McEwen Stem Cell Institute, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Ajmera Transplant Centre, Toronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 2C4, Canada. Electronic address:
Organogenesis is a complex process that relies on a dynamic interplay between extrinsic factors originating from the microenvironment and tissue-specific intrinsic factors. For pancreatic endocrine cells, the local niche consists of acinar and ductal cells as well as neuronal, immune, endothelial, and stromal cells. Hematopoietic cells have been detected in human pancreas as early as 6 post-conception weeks, but whether they play a role during human endocrinogenesis remains unknown.
View Article and Find Full Text PDFPaediatric trigger thumbs: patient-reported outcome measures over a minimum of ten years' follow-up.
Bone Jt Open
September 2024
Department of Orthopedics, All India Institute of Medical Sciences, Deoghar, India.
Aims: The paediatric trigger thumb is a distinct clinical entity with unique anatomical abnormalities. The aim of this study was to present the long-term outcomes of A1 pulley release in idiopathic paediatric trigger thumbs based on established patient-reported outcome measures.
Methods: This study was a cross-sectional, questionnaire-based study conducted at a tertiary care orthopaedic centre.
Paediatric trigger thumb: Diagnostic pearls.
J Paediatr Child Health
November 2024
Department of Orthopaedics and Rehabilitation, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.
Aim: The purpose of this study is to report diagnostic pearls and review the clinical presentation and outcomes of surgical treatment of paediatric trigger thumbs.
Methods: A retrospective review of medical records and imaging studies was performed on children with trigger thumbs from January 2009 to December 2019.
Results: Sixty-four trigger thumbs in 52 consecutive patients were treated.
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