Only one of two keys reinforces the subject with food. This key can assume one of two colors, each associated with a different fixed-ratio schedule for obtaining reinforcement. The function of the second key is to permit the animal to switch from the long schedule to the short schedule. If the difference between the ratio schedules is large enough, a preference for the shorter schedule is demonstrable. A quantitative index of preference is obtained as follows: each time the animal switches to the shorter schedule, the number of pecks required to produce the next switch is increased. As the "ante" on the switching key increases, the effective difference between the two ratio schedules decreases. After each food reinforcement, when the bird is exposed to the choice-situation, it takes longer before the bird switches again. This is used to "titrate" the bird's preference. If it does not switch within x sec, the progressively increasing ratio schedule of the switching key is decreased. A specific value, in terms of a rather specific number of responses the bird settles at on the choice key, is obtained. This equilibrium is employed as a dependent variable. Several variables of which it is a function are explored.
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http://dx.doi.org/10.1901/jeab.1963.6-525 | DOI Listing |
J Mater Chem B
January 2025
Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Department of Ophthalmology, Reina Sofia University Hospital and University of Cordoba, 14004 Cordoba, Spain.
Gold nanoparticles (AuNPs) play a key role in the field of nanomedicine due to their fascinating plasmonic properties as well as their great biocompatibility. An intriguing application is the use of plasmonic photothermal therapy (PPTT) mediated by anisotropic AuNPs irradiated with a near-infrared (NIR) laser for treating ocular diseases in ophthalmology. For this purpose, bipyramidal-shaped AuNPs (BipyAu), which were surface-functionalized with three different organic ligands (citrate, polystyrene sulphonate (PSS), and cetyltrimethylammonium bromide (CTAB)), were synthesized.
View Article and Find Full Text PDFHypertension
January 2025
Department of Medicine, Unit of Internal Medicine B, University of Verona School of Medicine, Azienda Ospedaliera Universitaria Integrata Verona, Policlinico G.B. Rossi, Italy.
Background: Hypertension is a major global health issue. Aldosterone synthase inhibitors (ASIs) have emerged as a promising therapeutic strategy for blood pressure control.
Methods: A thorough search of the MEDLINE and Embase databases up to March 30, 2024, identified randomized trials comparing ASIs with a placebo for hypertension treatment.
Front Oncol
January 2025
Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Objective: To investigate the optimal cut-off value of immunohistochemical marker Ki67 as a prognostic factor to predict the recurrence of non-muscle invasive bladder urothelial carcinoma (NMIBUC).
Methods: A total of 331 patients diagnosed with NMIBUC who underwent surgery in the Yongchuan Hospital and the Second Affiliated Hospital of Chongqing Medical University from January 2012 to January 2020 were finally included in this study. The optimal cut-off value of Ki67 for predicting recurrence of NMIBUC was calculated by ROC curve and Youden index.
Indian J Urol
January 2025
Faculty of Medicine, Tanta University, Tanta, Egypt.
Background And Objective: Primary hyperoxaluria (PH), a rare autosomal recessive disorder, results in defective metabolism of oxalate, leading to increased oxalate levels. is a nonpathological anaerobic bacterium that uses oxalate for its survival and thus decreases the plasma oxalate levels. We aimed to use randomized controlled trials (RCTs) to evaluate the efficacy of in treating PH.
View Article and Find Full Text PDFNanoscale Adv
January 2025
Univ. Bordeaux, CNRS, Bordeaux INP, ICMCB UMR 5026 F-33600 Pessac France
Colloidal chemistry provides an assortment of synthetic tools for tuning the shape of semiconductor nanocrystals. To fully exploit the shape- and structure-dependent properties of semiconductor nanorods, high-precision control on growth and design is essential. However, achieving this precision is highly challenging due to the high temperatures (>350 °C) and short reaction times (<8 minutes) often required for these reactions.
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