Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Background: Circadian function, characterized by circadian strength, timing, and fragmentation, has been shown to correlate with cognitive function; however, little is known about in these associations, particularly among older adults who may have more variability in their sleep-wake schedules.
Method: Among 60 community-living adults aged 60-90 years with self-reported sleep complaints ≥once/ week, we investigated gender differences in the associations between circadian and cognitive function. Participants completed seven days of actigraphy and one night of polysomnography.
Biomarkers.
Alzheimers Dement
December 2024
Sorbonne University, GRC n°21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Boulevard de L'hôpital, F-75013, Paris, France.
Background: Neuropsychiatric symptoms (NPS), including depression and circadian rhythm disruptions, are early non-cognitive markers along the Alzheimer's Disease (AD) continuum. These pathological states are thought to resemble AD pathogenesis, both of which are characterized by a marked decline in adult hippocampal neurogenesis.
Method: 96 elderly participants divided into three groups based on the global depression scale, neuropsychiatric inventory, clinical dementia rating, and mini-mental status examination.
Background: People living with dementia (PWD) often have inactivity-induced muscle atrophy, increased sedentary behavior, and circadian rhythm disorders. Exercise may improve physical activity, sedentary behavior, and sleep in PWD, but further research is needed. The purpose of this pilot randomized controlled trial (RCT) was to examine whether a structured exercise program improves physical activity, sedentary behavior, and sleep in PWD.
View Article and Find Full Text PDFCircadian rest-activity rhythm pattern in the elderly with cerebral small vessel disease: Using multiple estimated methods.
J Alzheimers Dis
January 2025
Department of Neurology, The Seventh Medical Center of PLA General Hospital, Beijing, China.
Disruption of circadian rest-activity rhythm (RAR) has been found in many neurological disorders. In this study, actigraphic data were collected and analyzed to identify the RAR pattern in the elderly with cerebral small vessel disease. 115 cerebral small vessel disease (CSVD) cases were recruited.
View Article and Find Full Text PDFBackground: Previous studies have linked disrupted circadian rest-activity rhythms (RARs) with increased risks for Alzheimer's disease and related dementias. However, these findings may be confounded due to the observational nature and offer limited insights into causality. We aimed to employ target trial emulation to estimate potential causal effects of RARs on dementia development.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!