Radioimmunoassay was used to measure thyroid, somatotropic, parathyroid hormones and cyclic nucleotides in 40 patients with hypertrophic cardiomyopathy and 14 with hypertensive disease concurrent with asymmetrical myocardial hypertrophy. In the patients with hypertrophic cardiomyopathy, the mean blood concentration of thyroid, somatotropic, parathyroid hormones and cyclic nucleotides was generally within the normal ranges and similar to that in hypertensive patients with apparently healthy individuals. The patients with hypertrophic cardiomyopathy concurrent with supraventricular arrhythmias exhibited higher blood levels of total and free thyroxine and thyroxine/thyroxine-bound globulin ration than did patients without arrhythmias. The patients with hypertrophic cardiomyopathy concurrent with arrhythmias displayed increased blood levels of cyclic nucleotides. The findings suggest that thyroid hormones and cyclic nucleotides are likely to make contribution to the pathogenesis of arrhythmias in hypertrophic cardiomyopathy.
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