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Assessment of heavy metal concentrations, environmental risks and human health implications in marine sediments along the coastal ecosystems of the Republic of Congo.
Environ Monit Assess
November 2024
Faculty of Sciences and Technology, Marien Ngouabi University, B.P 69, Brazzaville, Republic of Congo.
The aim of this study is to assess the level of heavy metals (HMs) in surface sediments along the coastal estuaries of the Republic of Congo. A variety of approaches were employed, integrating elemental analysis (Atomique Absorption Spectroscopy), environmental, ecological, health risk assessment, and source identification techniques to evaluate the distribution, origin, environmental, ecological and health risks of potentially toxic element (PTE) contamination in sediments. The ascending mean concentration (mg/kg) of Cd (0.
View Article and Find Full Text PDFUnravelling the Role of Chitin and Chitosan in Prebiotic Activity and Correlation With Cancer: A Narrative Review.
Nutr Rev
November 2024
Department of Veterinary Medicine and Animal Sciences (DIVAS), University of Milan, Lodi 26900, Italy.
This review describes the state of the art regarding the prebiotic role of chitin and the interactions of chitin and chitosan with cancer cells. Chitin is the second most abundant polysaccharide in nature and a constitutive component of crustacean shells and the exoskeleton of insects. Chitosan is the deacetylated form of chitin, which is obtained by chemical processing or the enzymatic activity of deacetylases found in microorganisms and insects.
View Article and Find Full Text PDFS-Adenosylmethionine Treatment Diminishes the Proliferation of Castration-Resistant Prostate Cancer Cells by Modulating the Expression of miRNAs.
Arch Immunol Ther Exp (Warsz)
January 2024
Department of Anatomy and Developmental Biology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
AdoMet (S-adenosylmethionine) inhibits cancer cell proliferation and migration via epigenetic alterations. This study aimed to investigate whether AdoMet may cause alterations in microRNA (miRNA) expression profiles that are important for the initiation and progression of prostate cancer. PC-3 cells were treated with AdoMet before miRNA sequencing.
View Article and Find Full Text PDFHepatic Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor Levels Decline in Hepatitis C but Are Not Associated with Progression of Hepatocellular Carcinoma.
Biomedicines
October 2024
Department of Internal Medicine I, Regensburg University Hospital, 93053 Regensburg, Germany.
Background/objectives: Bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) is an antagonist of transforming growth factor (TGF)-β type 1 signaling. BAMBI functions as an anti-fibrotic protein and exerts pro- as well as anti-cancerogenic activities. Our study aimed to correlate hepatocyte BAMBI protein levels in hepatocellular carcinoma (HCC) with T stage, lymph node invasion, vessel invasion, grading, tumor size and Union for International Cancer Control (UICC) stage, as well as with liver inflammation and fibrosis stages.
View Article and Find Full Text PDFAlterations of receptors and insulin-like growth factor binding proteins in senescent cells.
Eur J Cell Biol
September 2024
Poznan University of Medical Sciences, Department of Pathophysiology of Ageing and Civilization Diseases, Święcickiego 4 Str., Poznań 60-781, Poland. Electronic address:
The knowledge about cellular senescence expands dynamically, providing more and more conclusive evidence of its triggers, mechanisms, and consequences. Senescence-associated secretory phenotype (SASP), one of the most important functional traits of senescent cells, is responsible for a large extent of their context-dependent activity. Both SASP's components and signaling pathways are well-defined.
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