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Diuretic activity of ethanolic extract and fraction enriched in saponins from Solanum sisymbriifolium Lam. root in rats.
Eur Rev Med Pharmacol Sci
November 2024
Department of Pharmacology, Faculty of Chemical Sciences, National University of Asuncion, UNA Campus, San Lorenzo, Paraguay.
Objective: Solanum sisymbriifolium Lam. is a native perennial plant with chemical characteristics of therapeutic importance. In Paraguayan traditional medicine, it is attributed to antihypertensive and diuretic activities.
View Article and Find Full Text PDFAssessment of the Diuretic Effect of the Leaves of Ehrenb (Cucurbitaceae) in Rats: Using Aqueous and 80% Methanol Extracts.
J Exp Pharmacol
August 2024
Department of Pharmacology and Clinical Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Background: The diuretic activity of the leaf, which is used in indigenous medicine, has been claimed but has not yet undergone scientific evaluation.
Objective: The objective of this study was to assess the diuretic activity of the aqueous and 80% methanol extracts derived from the leaves of in rats.
Methods: For the extraction process, the maceration technique was employed to obtain the aqueous and 80% methanol extracts from the leaves.
Calcineurin inhibitor effects on kidney electrolyte handling and blood pressure: tacrolimus versus voclosporin.
Nephrol Dial Transplant
December 2024
Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Background: Calcineurin inhibitors (CNIs) affect kidney electrolyte handling and blood pressure (BP) through an effect on the distal tubule. The second-generation CNI voclosporin causes hypomagnesaemia and hypercalciuria less often than tacrolimus. This suggests different effects on the distal tubule, but this has not yet been investigated experimentally.
View Article and Find Full Text PDFEvaluation of Diuretic Activity of Aqueous and Hydro Methanolic Crude Extracts and Solvent Fraction of the Hydromethanolic Flower Extract of in Swiss Albino Mice.
J Exp Pharmacol
April 2024
Department of Pharmacology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Purpose: To evaluate the diuretic effects of aqueous (AQ) and hydromethanolic crude extract (HM) the as well as the solvent fractions of the HM extract from Erica arborea flowers in mice.
Methods: Mice were administered AQ and HM crude extracts, along with solvent fractions of HM extracts of flowers, including HXF (n-hexane fraction), EAF (ethyl acetate fraction), and AQF (aqueous fraction), at doses ranging from 100 to 400 mg/kg orally. The effects of these extracts and solvent fractions on urine and salt excretion over 5 hours were compared to the effects of the solvent used for reconstitution and a standard drug (furosemide 10 mg/kg), as well as to each other.
Antioxidant, carbonic anhydrase inhibition and diuretic activity of Forssk. Decne.
Heliyon
December 2023
Department of Pharmacology, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
Background: Forssk. Decne is a member of family Apocynaceae and locally known as 'Khipp'. It is found in dry, sandy habitat of Pakistan and in several other regions around the world including Asia, Tropical Africa, Western Gulf and Mediterranean countries.
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