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Acoustofluidic Chromatography for Extracellular Vesicle Enrichment from 4 μL Blood Plasma Samples.
Anal Chem
March 2025
Acoustofluidics Group, Lund University, Lund 221 00, Sweden.
We present a novel acoustofluidic chromatography platform for high-throughput nanoparticle trapping and enrichment, with a focus on extracellular vesicles (EVs) from blood plasma. The system features a packed bed of polystyrene beads inside a rectangular glass capillary, acoustically actuated by a piezoelectric element. Using fluorescent polystyrene nanoparticles as small as 25 nm, we characterized device performance across a frequency range of 0.
View Article and Find Full Text PDFAntigenicity and genetic properties of an Eurasian avian-like H1N1 swine influenza virus in Jiangsu Province, China.
Biosaf Health
December 2024
National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Pigs are vital genetic mixing vessels for human and avian influenza viruses because their tracheal epitheliums possess both sialic acid α-2,6-Gal and α-2,3-Gal receptors. Cross-species transmission of influenza A viruses from swine to humans occurs occasionally. The first case of human infection with the Eurasian avian-like H1N1 swine influenza virus (EAH1N1 SIVs) genotype G4 was detected in Jiangsu Province, China, in February 2023, and backtracking epidemiological investigations did not reveal a clear source of the infection.
View Article and Find Full Text PDFGenomic identification of a pair of multidrug-resistant but non-pathogenic serovar Goldcoast isolates in southeast China.
Front Microbiol
February 2025
Medical Research Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
Introduction: is an important foodborne pathogen that can induce severe diseases such as gastrointestinal disease and typhoid fever. Accumulating evidence revealed that 's resistance to antibiotics also seriously affects human health. Pathogenic serovar Goldcoast ( Goldcoast) was first detected in 2010 in China and was predicted to have an increasing tendency.
View Article and Find Full Text PDFImpact of Prenatal Dietary Soy on Cerebellar Neurodevelopment and Function in Experimental Fetal Alcohol Spectrum Disorder.
Nutrients
February 2025
Departments of Neuroscience and Biology, Brown University, Providence, RI 02903, USA.
Prenatal alcohol exposure (PAE) models can cause neurodevelopmental abnormalities like those observed in fetal alcohol spectrum disorder (FASD). Previous studies link experimental PAE effects in the brain to impaired signaling through insulin/IGF and Notch pathways that mediate neuronal survival, growth, migration, energy metabolism, and plasticity. Importantly, concurrent administration of peroxisome proliferator-activated receptor agonists or dietary soy prevented many aspects of FASD due to their insulin-sensitizing, anti-inflammatory, and antioxidant properties.
View Article and Find Full Text PDFDifferential Enzymatic Hydrolysis: A Study on Its Impact on Soy Protein Structure, Function, and Soy Milk Powder Properties.
Foods
March 2025
College of Food Science, Northeast Agricultural University, Harbin 150030, China.
Protein constitutes the primary nutrient in soy, and its modifications are intricately linked to the properties of the soy milk powder. This study employed six main commercial enzymes (bromelain, neutrase, papain, trypsin, flavourzyme, and alcalase) to investigate the impact of enzymatic hydrolysis on the structural and functional properties of soy protein isolate (SPI), as well as its influence on the physicochemical properties of soy milk powder. The findings indicated that each of enzymes exhibits distinct specificity, with the degree of hydrolysis following the order: alcalase > flavourzyme > papain > bromelain > neutrase > trypsin.
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