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The primiparous IgA and IL-5 colostrum concentration based on maternal factor: corroborate the inflammation pathways to IgA colostrum synthesis.
AJOG Glob Rep
February 2025
Center for Biomedical Research, Research Organization for Health, National Research and Innovation Agency (BRIN) (Nurwidyaningtyas), Bogor, West Java, Indonesia.
Background: Immunoglobulin A (IgA) plays a crucial role in the maturation the neonatal mucosal barrier. The accumulation of IgA antibody-secreting cells (ASCs) in the lactating mammary gland facilitates the secretion of IgA antibodies into milk, which are then passively to the suckling newborn, providing transient immune protection against gastrointestinal pathogens. Physiologically, full-term infants are unable to produce IgA, required for mucosal barrier maturation for at least 10 days after birth.
View Article and Find Full Text PDFThird-trimester resolution of low placentation and risk of postpartum hemorrhage.
Eur J Obstet Gynecol Reprod Biol
January 2025
Montefiore Medical Center/Albert Einstein College of Medicine, Division of Fetal Medicine and Ultrasound, Department of Obstetrics and Gynecology and Women's Health.
Objective: Low placentation is associated with increased risk of postpartum hemorrhage (PPH). There is a paucity of data on the association between second trimester low placentation that later resolves, and PPH. Our objective was to investigate the association of resolved low placentation and other prenatal ultrasound markers, and PPH with delivery.
View Article and Find Full Text PDFThe immune landscape of fetal chorionic villous tissue in term placenta.
Front Immunol
January 2025
Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY, United States.
Introduction: The immune compartment within fetal chorionic villi is comprised of fetal Hofbauer cells (HBC) and invading placenta-associated maternal monocytes and macrophages (PAMM). Recent studies have characterized the transcriptional profile of the first trimester (T1) placenta; however, the phenotypic and functional diversity of chorionic villous immune cells at term (T3) remain poorly understood.
Methods: To address this knowledge gap, immune cells from human chorionic villous tissues obtained from full-term, uncomplicated pregnancies were deeply phenotyped using a combination of flow cytometry, single-cell RNA sequencing (scRNA-seq, CITE-seq) and chromatin accessibility profiling (snATAC-seq).
Association between interpregnancy interval and adverse perinatal outcomes according to maternal age in the context of China's two-child policy.
BMC Pregnancy Childbirth
January 2025
Department of Health Care, School of Medicine, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Background: Since the implementation of China's comprehensive two-child policy, the prevalence of long interpregnancy intervals (IPI) and advanced maternal age has increased. However, previous studies in China have mostly focused on the relationship between short IPIs and adverse perinatal outcomes, while neglecting maternal age as a potential confounder.
Methods: We conducted a retrospective cohort study of 23,899 pregnant women who delivered between January 1, 2017 and December 31, 2019 at Chengdu Women's and Children's Central Hospital and West China Second Hospital of Sichuan University.
Sensitive Months for Green Spaces' Impact on Macrosomia and Interaction with Air Pollutants: A Birth Cohort Study.
Environ Pollut
January 2025
School of Public Health, Ningxia Medical University, Yinchuan, Ningxia, 750004, China; The Peking University First Hospital Ningxia Women and Children's Hospital, Yinchuan, Ningxia, 751000, China. Electronic address:
Macrosomia poses significant health risks to mother and fetuses, yet the protective sensitive window for the effects of green space resources on the risk of macrosomia remains unexplored. This study identified sensitive windows of green space exposure and examined the interactions with air pollutants. In a study of 221,380 full-term newborns delivered at the Hospital, from 2017 to 2021, Normalized Difference Vegetation Index (NDVI) and atmospheric pollutant concentrations were matched to participants based on their residences in the Ningxia region.
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