Himalayan rabbits immunized with homogenates prepared from nymphs of Amblyomma hebraeum Koch and A. marmoreum Koch ticks developed humoral and probably also cell-mediated immunity to their respective homogenates. Beta and gamma globulin levels and numbers of eosinophils and neutrophils increased significantly in inoculated rabbits. The recipient animals developed resistance to homospecific nymphal infestations. Cross resistance between the two species was not evaluated. Nymphs of both species that fed on inoculated rabbits demonstrated slightly shorter feeding periods, and their mean weights were significantly lower than nymphs that fed on Quil 'A' adjuvant-inoculated rabbits or on naive rabbits. Significantly higher proportions of nymphs from immunized animals failed to moult when compared with nymphs that fed on the two control groups. These parameters indicate that the inoculated rabbits had acquired protective immunity against nymphs of both ticks.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/jmedent/29.5.757 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A core glycolipid vaccine elicits cross-reactive antibodies against Salmonella spp. and protects against invasive nontyphoidal Salmonella disease in mice.
J Infect Dis
December 2024
Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Background: Enteric fever caused by Salmonella enterica serovars Typhi and Paratyphi A in addition to gastroenteritis and invasive disease, predominantly attributable to nontyphoidal Salmonella serovars Typhimurium and Enteritidis, are major causes of death and disability across the globe. A broad-spectrum vaccine that protects against disease caused by typhoidal and nontyphoidal serovars of Salmonella is not available for humans but would prevent a considerable burden of disease worldwide.
Methods: We previously developed a broad-spectrum vaccine for Gram-negative bacteria that is based on the inner core domain of detoxified Escherichia coli O111, Rc (J5) mutant lipooligosaccharide, a highly conserved antigen across Gram-negative bacteria, complexed with an outer membrane protein of group B Neisseria meningitidis.
The efficacy of egg albumin nanoparticles adjuvanted Clostridium perfringens type D toxoid vaccine in rabbits.
Braz J Microbiol
December 2024
Institute of Microbiology, Faculty of Veterinary Science, University of Agriculture, Faisalabad, 38040, Pakistan.
Epsilon toxin (ETX) is an exotoxin produced by Clostridium perfringens type D that induces enterotoxaemia or necrotic intestinal infection in small ruminants and bovine. Immunization is an essential element in preventing the spread of infectious diseases. In recent literature, nanocarriers have exhibited the capacity to deliver protection, stability, and regulated distribution properties to protein-based antigens.
View Article and Find Full Text PDFThe adjuvant effect of manganese on tuberculosis subunit vaccine Bfrb-GrpE.
NPJ Vaccines
December 2024
Key Laboratory of Blood-stasis-toxin Syndrome of Zhejiang Province, School of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Protein subunit vaccines, lacking pathogen-associated molecular patterns that trigger immune responses, rely on adjuvants to induce robust immune responses against the target pathogen. Thus, selection of adjuvants plays a crucial role in the design of protein subunit vaccines. Recently, there has been growing interest in utilizing cGAS-STING agonists as vaccine adjuvants.
View Article and Find Full Text PDFInvestigating Flavor Enhancement Methods in NaCl-Reduced Chinese Bacon () by Focusing on Physicochemical Characteristics, Bacterial Diversity, and Volatiles.
Foods
November 2024
College of Food Science, Southwest University, No. 2 Tiansheng Road, Beibei District, Chongqing 400715, China.
Article Synopsis
- The study focuses on optimizing sodium chloride (NaCl) levels in Chinese bacon to improve flavor while reducing health risks associated with high salt consumption.
- Chinese bacon was categorized into three types based on NaCl concentration: low, medium, and high, each exhibiting distinct physicochemical characteristics, predominant bacteria, and volatile compounds.
- Effective flavor enhancement strategies for low-NaCl bacon involve adjusting specific physicochemical markers and inoculating with certain bacteria, while balancing quality and safety concerns.
The first artificial cancer in the internal organs of experimental animals.
Proc Jpn Acad Ser B Phys Biol Sci
December 2024
Ex-Chief, National Cancer Center Research Institute, Tokyo, Japan.
Article Synopsis
- In the early 20th century, Japan made significant contributions to cancer research, starting with the 1915 experiment by Yamagiwa and Ichikawa, which induced skin cancer in rabbits using coal tar.
- In 1932, Sasaki and Yoshida discovered liver cancer in rats through a specific diet involving a chemical compound, marking the first artificial cancer found in internal organs.
- Finally, in 1967, Sugimura induced stomach cancer in mice with a chemical mutagen, reinforcing the link between DNA abnormalities and cancer development.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!