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Background: Homozygosity for the rare APOE3-Christchurch (APOE3Ch) variant, encoding for apoE3-R136S (apoE3-Ch), was linked to resistance against an aggressive form of familial Alzheimer's disease (AD). Carrying two copies of APOE3Ch was sufficient to delay autosomal AD onset by 30 years. This remarkable protective effect makes it a strong candidate for uncovering new therapies against AD.
View Article and Find Full Text PDFAnticoagulation and associated complications in veno-arterial extracorporeal membrane oxygenation in adult patients: A systematic review and meta-analysis.
Crit Care Resusc
December 2024
The George Institute for Global Health, Critical Care Program, Australia.
Objective: To describe the incidence of bleeding and thrombotic complications in VA-ECMO according to anticoagulation strategy.
Design: This systematic review and meta-analysis included randomised controlled trials (RCTs) and observational studies reporting bleeding and thrombotic complications in VA-ECMO. The incidence of primary outcomes according to anticoagulation drug and monitoring test was described.
[Predictive value of plasma heparin-binding protein combined with albumin for 28-day mortality in patients with sepsis].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
December 2024
Department of Emergency Medicine, People's Hospital of Shenzhen Baoan District (the Second Affiliated Hospital of Shenzhen University), Shenzhen 518101, Guangdong, China. Corresponding author: Dou Qingli, Email:
Objective: To evaluate the predictive value of plasma heparin-binding protein (HBP) combined with albumin (Alb) for predicting 28-day mortality in patients with sepsis.
Methods: The clinical data of patients with sepsis admitted to the emergency intensive care unit (EICU) of the People's Hospital of Shenzhen Baoan District from March 2020 to March 2024 were retrospectively analyzed. The study began at the time of the first diagnosis of sepsis upon EICU admission and ended upon patient death or at 28 days.
Development of a rapid enzymatic quantification method for hyaluronic acid based on the gene-mining of hyaluronate lyase.
Carbohydr Polym
March 2025
College of Food Science and Engineering, Ocean University of China, Qingdao, 266404, PR China; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, 168 Wenhai Middle Road, Qingdao, 266237, China.
Hyaluronic acid (HA), a vital polysaccharide naturally present in human tissues, is widely utilized in the food, pharmaceutical and cosmetic industries due to its diverse functionalities and bioactivity. Rapid and accurate quantification of HA is essential for the quality control of its products. Enzymatic quantification methods, known for their simplicity and high specificity, were employed for polysaccharide measurement.
View Article and Find Full Text PDFLarge Peritoneal Macrophages Play No Role in the Pathogenesis of Postoperative Ileus Induced by Intestinal Manipulation.
Neurogastroenterol Motil
January 2025
Center for Intestinal Neuro-Immune Interactions, Translational Research Center for GI Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.
Introduction: Postoperative ileus (POI) is an iatrogenic disorder marked by temporary impaired gastrointestinal (GI) motility post-abdominal surgery. Surgical handling of the intestine activates resident macrophages (Mfs), leading to inflammatory cytokine release and leukocyte recruitment into the muscularis, which compromises intestinal contractility. The mechanisms behind this activation are unclear.
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