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Simultaneous noninvasive quantification of redox and downstream glycolytic fluxes reveals compartmentalized brain metabolism.
Sci Adv
December 2024
Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Brain metabolism across anatomic regions and cellular compartments plays an integral role in many aspects of neuronal function. Changes in key metabolic pathway fluxes, including oxidative and reductive energy metabolism, have been implicated in a wide range of brain diseases. Given the complex nature of the brain and the need for understanding compartmentalized metabolism noninvasively in vivo, new tools are required.
View Article and Find Full Text PDFMitigation of aluminum toxicity in rice seedlings using biofabricated selenium nanoparticles and nitric oxide: Synergistic effects on oxidative stress tolerance and sulfur metabolism.
Chemosphere
February 2025
Department of Botany, University of Gour Banga, Malda, 732103, West Bengal, India.
Biofabricated selenium nanoparticles (Se-NPs) and sodium nitroprusside-derived nitric oxide (NO) singly or in combination was evaluated to improve tolerance to aluminum (Al) stress in rice (Oryza sativa L. cv. Swarna Sub1).
View Article and Find Full Text PDFPreassembled complexes of hAgo2 and ssRNA delivered by nanoparticles: a novel silencing gene expression approach overcoming the absence of the canonical pathway of siRNA processing in the apicomplexan parasite Babesia microti, blood parasite of veterinary and zoonotic importance.
Emerg Microbes Infect
December 2025
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
Article Synopsis
- Current chemical drugs are ineffective for tick control and there are no effective vaccines, leading to the urgent need for new control strategies.
- Small interfering RNAs (siRNAs) have potential to help control parasites, but their effectiveness is limited by challenges in getting them to the RNA-induced silencing complex (RISC).
- This study developed a delivery system using chitosan nanoparticles to successfully transfect siRNAs into parasites, which reduced target gene expression and inhibited parasite growth, opening new avenues for gene therapy and understanding host-parasite interactions.
Morphological, biochemical and genotoxic effects of non-ionizing radiation at 1800 MHz and 2400 MHz frequencies in Allium cepa L.
Environ Sci Pollut Res Int
November 2024
Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.
Article Synopsis
- The study examines the effects of electromagnetic radiation (EMR) from common devices on Allium cepa L. (onion plants) at frequencies of 1800 MHz and 2400 MHz, across varying exposure durations.
- Prolonged exposure to EMR led to reduced root length, fresh weight, and dry weight, along with decreased protein content and increased activity of antioxidative enzymes during higher exposure times.
- The research also indicated that long-term EMR exposure caused oxidative stress and chromosomal abnormalities in the root tip cells, highlighting potential genotoxic effects on the plants.
Ethylene and hydrogen sulfide regulate hexavalent chromium toxicity in two pulse crops: Implication on growth, photosynthetic activity, oxidative stress and ascorbate glutathione cycle.
Plant Physiol Biochem
November 2024
Plant Physiology Laboratory, Department of Botany, C.M.P. Degree College, A Constituent Post Graduate College of University of Allahabad, Prayagraj, 211002, India.
Article Synopsis
- Sustainable agriculture is crucial for addressing the challenges of feeding a growing population, which is why researchers are looking at the use of external hormones and signaling molecules.
- This study focused on how ethylene and hydrogen sulfide (HS) can help reduce the toxicity of hexavalent chromium (Cr(VI)) in black bean and mung bean seedlings, with Cr(VI) causing significant growth and photosynthetic issues, especially in mung beans.
- The application of ethylene and HS showed a positive effect by decreasing Cr toxicity through reducing harmful oxidative stress markers and enhancing the activity of protective cycles, while the use of biosynthesis inhibitors highlighted the importance of these regulators for plant tolerance to Cr(VI).
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