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Evaluating a Hearing Loop Implementation for Live Orchestral Music.
Ear Hear
January 2025
McMaster Institute for Music and the Mind, McMaster University, Hamilton, Ontario, Canada.
Objectives: Live music creates a sense of connectedness in older adults, which can help alleviate the social isolation frequently associated with hearing loss and aging. However, most hearing-aid (HA) users are dissatisfied with the sound quality of live music and rate sound quality as important to them. Assistive listening systems are frequently independent of a user's HAs and fall short in tailoring to each individual's hearing loss.
View Article and Find Full Text PDFLeadership roles in response to mpox and Marburg virus disease outbreaks.
Lancet
January 2025
Africa Centres for Disease Control and Prevention, Addis Ababa 1000, Ethiopia.
The levels of the long non-coding RNA MALAT1 affect cell viability and modulate TDP-43 binding to mRNA in the nucleus.
J Biol Chem
January 2025
Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA. Electronic address:
TAR DNA-binding protein (TDP-43) and Metastasis Associated Lung Adenocarcinoma Transcript (MALAT1) RNA are both abundantly expressed in the human cell nucleus. Increased interaction of TDP-43 and MALAT1, as well as dysregulation of TDP-43 function, was previously identified in brain samples from patients with neurodegenerative disease compared to healthy brain tissues. We hypothesized that TDP-43 function may depend in part on MALAT1 expression levels.
View Article and Find Full Text PDFProtecting monoclonal antibodies via competitive interfacial adsorption of nonionic surfactants.
J Colloid Interface Sci
December 2024
Biological Physics Laboratory, Department of Physics and Astronomy, University of Manchester, Oxford Road, Schuster Building, Manchester M13 9PL, UK. Electronic address:
Hypothesis: Bioengineered monoclonal antibodies (mAbs) have gained significant recognition as medical therapies. However, during processing, storage and use, mAbs are susceptible to interfacial adsorption and desorption, leading to structural deformation and aggregation, and undermining their bioactivity. To suppress antibody surface adsorption, nonionic surfactants are commonly used in formulation.
View Article and Find Full Text PDFRecurrent peripheral intravenous catheterization in neonates: A case series.
Nurs Crit Care
January 2025
Women's and Newborns Service, Grantley Stable Neonatal Unit, Nursing and Midwifery Research Centre; Royal Brisbane and Women's Hospital, Herston, Australia.
Neonatal peripheral intravenous catheters (PIVCs) can be difficult to insert, often requiring multiple attempts, with each attempt causing pain and delaying treatment. The aim of this study was describe the clinical characteristics of neonates requiring multiple PIVCs during hospitalization. A secondary case series of neonates requiring three or more PIVCs during their admission were identified from a cohort admitted to an Australian Neonatal Unit between October 2020 and February 2021.
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