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Analysis of Pz-1, a promising therapeutic for organophosphorus poisoning from rodent plasma by liquid chromatography-tandem mass spectrometry.
J Pharm Biomed Anal
March 2025
Department of Chemistry, Biochemistry and Physics, South Dakota State University, Box 2202, Brookings, SD 57007, USA. Electronic address:
Organophosphorus (OP) pesticides (e.g., parathion) and nerve agents (e.
View Article and Find Full Text PDFDevelopment of a Generic Physiologically Based Kinetic Model for the Prediction of Internal Exposure to Organophosphate Pesticides.
Environ Sci Technol
October 2024
Division of Toxicology, Wageningen University and Research, Stippeneng 4, 6708 WE Wageningen, The Netherlands.
Article Synopsis
- The study explores the development of a generic physiologically based kinetic (PBK) model for assessing the effects of organophosphate (OP) pesticides on both rats and humans.
- It utilizes data from existing studies and quantitative structure property relationships to evaluate how well the model predicts the absorption and toxicity of various OP compounds, showing high accuracy in most cases.
- The findings suggest this PBK model can be a valuable tool for next generation risk assessment (NGRA) of OP pesticides and potentially be adapted for other chemical classes.
Introduction: Intentional and unintentional organophosphorus pesticide exposure is a public health concern. Organothiophosphate compounds require metabolic bioactivation by the cytochrome P450 system to their corresponding oxon analogues to act as potent inhibitors of acetylcholinesterase. It is known that interactions between cytochrome P450 and pesticides include the inhibition of major xenobiotic metabolizing cytochrome P450 enzymes and changes on the genetic level.
View Article and Find Full Text PDFUnlocking the interaction of organophosphorus pesticide residues with ecosystem: Toxicity and bioremediation.
Environ Res
May 2024
Department of Soil Science and Land Resouces Management, Agriculture Faculty, Universitas Padjadjaran, Indonesia. Electronic address:
Organophosphorus adulteration in the environment creates terrestrial and aquatic pollution. It causes acute and subacute toxicity in plants, humans, insects, and animals. Due to the excessive use of organophosphorus pesticides, there is a need to develop environmentally friendly, economical, and bio-based strategies.
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