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Cytokine-Induced Glucocorticoid Resistance from Eosinophil Activation: Protein Phosphatase 5 Modulation of Glucocorticoid Receptor Phosphorylation and Signaling.
J Immunol
November 2016
Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, TX 77555;
The mechanisms contributing to persistent eosinophil activation and poor eosinopenic response to glucocorticoids in severe asthma are poorly defined. We examined the effect of cytokines typically overexpressed in the asthmatic airways on glucocorticoid signaling in in vitro activated eosinophils. An annexin V assay used to measure eosinophil apoptosis showed that cytokine combinations of IL-2 plus IL-4 as well as TNF-α plus IFN-γ, or IL-3, GM-CSF, and IL-5 alone significantly diminished the proapoptotic response to dexamethasone.
View Article and Find Full Text PDFAetiology of attenuated luteal development in prednisolone-induced eosinopenic ewes.
Reprod Fertil Dev
August 2001
Department of Animal Science, University of Wyoming, Laramie 82071, USA.
Eosinophilic leukocytes infiltrate the wall of postovulatory ovine follicles. The objective of this investigation was to assess a putative role of resident eosinophils in the folliculo luteal transition. Eosinophils accumulated where new blood vessels were evident along connective tissue trabeculae that pervaded the parenchyma of formative corpora lutea.
View Article and Find Full Text PDFHypereosinophilia in association with pulmonary tuberculosis in a rural population in south India.
Indian J Med Res
November 1994
Department of Chest Diseases, Christian Medical College, Vellore.
In a prospective study conducted in four villages of North Arcot Ambedkar district of Tamil Nadu in south India over a 5 yr period from 1981-86, 279 patients were detected to have pulmonary tuberculosis (PTB). Thirty one of them were found to have associated hypereosinophilia (HE) with total blood eosinophil level of > or = 2000 per cumm; besides cough with expectoration they also complained of dyspnoea and wheeze. Twelve of the 18 patients with intestinal parasites had remission with deworming agents alone.
View Article and Find Full Text PDFQuantification of theophylline-induced eosinopenia and hypokalaemia in healthy volunteers.
Clin Pharmacokinet
March 1992
Department of Pulmonology, University of Amsterdam, The Netherlands.
The relationship between theophylline pharmacokinetics and its eosinopenic and hypokalaemic effects were studied in 6 healthy volunteers after an oral dose of theophylline 250 mg. The mean peak theophylline concentration (Cmax) of 8.33 +/- 2.
View Article and Find Full Text PDFIt would be difficult for physicians or allergists to imagine doing without corticosteroids in managing difficult cases of bronchial asthma. It is beyond any doubt that CS act on many sites to help reverse the pathologic process of bronchial asthma. Corticosteroids enhance the beta-adrenergic response to relieve the muscle spasm.
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