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Neuronal Distribution in Colorectal Cancer: Associations With Clinicopathological Parameters and Survival.
Mod Pathol
October 2024
Department of Pathology, GROW-Research Institute for Oncology and Reproduction, Maastricht University Medical Center, Maastricht, The Netherlands; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address:
Over the past years, insights in the cancer neuroscience field increased rapidly, and a potential role for neurons in colorectal carcinogenesis has been recognized. However, knowledge on the neuronal distribution, subtypes, origin, and associations with clinicopathological characteristics in human studies is sparse. In this study, colorectal tumor tissues from the Netherlands Cohort Study on diet and cancer (n = 490) and an in-cohort validation population (n = 529) were immunohistochemically stained for the pan-neuronal markers neurofilament (NF) and protein gene product 9.
View Article and Find Full Text PDF[Imaging for displaying lymphatic vessels in whole-mount aorta adventitia of ApoE mice by immunofluorescent histochemical staining].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
June 2024
Department of Pharmacy; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China. *Corresponding author, E-mail:
Objective To explore a simple and feasible method for whole-mount immunofluorescence staining of lymphatic vessels in the ApoE mouse model of atherosclerosis. Methods Aortic specimens were carefully excised from the ApoE mouse model. Following immunostaining with specific antibodies against smooth muscle actin (SMA) and lymphatic vessel endothelial receptor 1 (LYVE1), the aortas, including the aortic root, were subjected to a 30-minute treatment with 5 g/L Sudan Black B solution.
View Article and Find Full Text PDFPotential of dapagliflozin to prevent vascular remodeling in the rat carotid artery following balloon injury.
Atherosclerosis
October 2024
UR 3074, Translational CardioVascular Medicine, Biomedicine Research Centre of Strasbourg, FMTS, Université de Strasbourg, Strasbourg, France; Université de Strasbourg, Pôle D'Activité Médico-Chirurgicale Cardio-Vasculaire, Nouvel Hôpital Civil, Centre Hospitalier Universitaire, Strasbourg, France; Hanoï Medical University, Hanoi, Viet Nam. Electronic address:
Article Synopsis
- Sodium-glucose co-transporter 2 (SGLT2) inhibitors, like dapagliflozin, may reduce the risk of cardiovascular issues and possibly prevent blood vessel thickening after injury, which is not well understood.
- In a study with male rats, dapagliflozin reduced neointima thickening by 32% compared to control and also impacted vascular responses without altering certain inflammatory and oxidative gene expressions.
- The findings suggest that dapagliflozin works by affecting angiotensin and extracellular nucleotide signaling, indicating SGLT2 inhibitors could be a new approach for addressing vascular restenosis.
Role of macrophage polarization in periodontitis promoting atherosclerosis.
Odontology
October 2024
Department of Preventive Dentistry, Hebei Key Laboratory of Stomatology, Hebei Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Hebei Medical University, No.383, Zhongshan East Road, Changan District, Shijiazhuang, Hebei, China.
Periodontitis is a chronic inflammatory destructive disease occurring in periodontal supporting tissues. Atherosclerosis(AS) is one of the most common cardiovascular diseases. Periodontitis can promote the development and progression of AS.
View Article and Find Full Text PDFQuantitative and large-format histochemistry to characterize peripheral artery compositional gradients.
Microsc Res Tech
December 2023
School of Mechanical, Medical and Process Engineering, Centre for Biomedical Technologies, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
The femoropopliteal artery (FPA) is a long, flexible vessel that travels down the anteromedial compartment of the thigh as the femoral artery and then behind the kneecap as the popliteal artery. This artery undergoes various degrees of flexion, extension, and torsion during normal walking movements. The FPA is also the most susceptible peripheral artery to atherosclerosis and is where peripheral artery disease manifests in 80% of cases.
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