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Cardioprotective potential of tectochrysin against vanadium induced heart damage via regulating NLRP3, JAK1/STAT3 and NF-κB pathway.
J Trace Elem Med Biol
January 2025
Department of Pathology, College of Medicine, King Khalid University, Asir 61421, Saudi Arabia; Department of Forensic Medicine and Clinical Toxicology, Mansoura University, Egypt.
Background: Vanadium (VAN) is a significant trace element, but its higher exposure is reported to cause severe organ toxicity. Tectochrysin (TEC) is a naturally derived flavonoid which demonstrates a wide range of pharmacological properties.
Aim: The current study was planned to assess the cardioprotective potential of TEC against VAN induced cardiotoxicity in rats via regulating biochemical, and histological profile.
Detection methods for carbapenem-resistant Pseudomonas aeruginosa in surface water and wastewater.
Sci Total Environ
January 2025
National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands; Department of Biotechnology, Technical University Delft, Delft, the Netherlands. Electronic address:
Water systems can act as an important reservoir for Pseudomonas aeruginosa, which can pose public health risks during human contact. Carbapenem resistance is one of the most concerning resistances in P. aeruginosa making it a high-priority pathogen according to the World Health Organization (WHO), due to its ability to cause difficult-to-treat infections.
View Article and Find Full Text PDFImplications of plastic ingestion on the growth and fledging success of shearwaters.
Sci Total Environ
January 2025
Institute for Marine and Antarctic Studies, University of Tasmania, Hobart, Australia; CSIRO Environment, Hobart, Australia.
Ingestion of plastic can have negative health consequences for wildlife. However, our understanding of the physiological impacts of plastics is limited, often relying on opportunistic sampling. We partnered with Tasmanian Aboriginal seabird harvesters, wildlife rescue clinics, and parks managers, to collect >400 fledgling yula/short-tailed and flesh-footed shearwaters across a spectrum of body conditions.
View Article and Find Full Text PDFStructural brain basis of latent factors of executive functions in childhood.
Dev Cogn Neurosci
December 2024
Division of Psychology and Language Sciences, UCL, London WC1H 0AP, UK. Electronic address:
Executive functions can be classified into processes of inhibition, working memory and shifting, which together support flexible and goal-directed behaviour and are crucial for both current and later-life outcomes. A large body of literature has identified distinct brain regions critical to performing each of these functions. These findings are however predicated on a piecemeal and single-task approach.
View Article and Find Full Text PDFAssessing the feasibility and external validity of natural language processing-extracted data for advanced lung cancer patients.
Lung Cancer
January 2025
Dept. of Medical Oncology, Princess Margaret Cancer Center, Toronto, ON, Canada.
Background: Manual extraction of real-world clinical data for research can be time-consuming and prone to error. We assessed the feasibility of using natural language processing (NLP), an AI technique, to automate data extraction for patients with advanced lung cancer (aLC). We assessed the external validity of our NLP-extracted data by comparing our findings to those reported in the literature.
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