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Metabolomics with gut microbiota analysis of podophyllotoxin-mediated cardiotoxicity in mice based on the toxicological evidence chain (TEC) concept.
Chem Biol Interact
January 2025
Luoyang Key Laboratory of Clinical Multiomics and Translational Medicine, Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, 471003, China. Electronic address:
Podophyllotoxin (PPT) is a lignan isolated from the traditional Chinese medicine Dysosma Versipellis, with significant anti-tumor activity. However, its cardiotoxicity restricts its clinical application. This study aims to investigate the cardiotoxicity of PPT in mice and its underlying mechanisms based on the concept of toxicological evidence chain (TEC).
View Article and Find Full Text PDFA case report of surgery-radiotherapy-chemotherapy cured primary diffuse large B-cell lymphoma of the central nervous system associated with HIV infection.
Diagn Pathol
November 2024
Department of Infectious Diseases, The Fourth People's Hospital of Nanning, Nanning, China.
Background: Diffuse large B-cell lymphoma (DLBCL) is one of the most common complications in patients with Acquired Immune Deficiency Syndrome (AIDS), yet its prognosis is generally poor. The impact of surgery on DLBCL remains controversial. We present a case of DLBCL associated with HIV infection, in which the patient achieved complete remission following surgical removal, radiotherapy, and sequential dose-adjusted EPOCH (DA-EPOCH) chemotherapy.
View Article and Find Full Text PDFEtoposide targets 2A protease to inhibit enterovirus 71 replication.
Microbiol Spectr
January 2025
Frontiers Science Center for Synthetic Biology (Ministry of Education), Haihe Laboratory of Sustainable Chemical Transformations, Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin, China.
Enterovirus 71 (EV71) is a major pathogen that causes hand, foot, and mouth disease (HFMD) in infants and children. Notably, no clinically approved drugs specifically target EV71. The EV71 2A protease (2A), a cysteine protease produced by the virus, is essential for the virus' replication and has a significant impact on the functioning of host cells.
View Article and Find Full Text PDFPlasmid-free production of the plant lignan pinoresinol in growing Escherichia coli cells.
Microb Cell Fact
October 2024
Institute of Biochemistry, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.
Article Synopsis
- The study focuses on developing a more cost-effective biotechnological pathway to produce (-)-podophyllotoxin, a valuable compound used in chemotherapy, using recombinant E. coli strains instead of expensive natural sources like (+)-pinoresinol.
- Researchers created a new toolbox for CRISPR/Cas9 to integrate genes directly into the E. coli chromosome, enabling simpler and more efficient multi-gene expression compared to traditional plasmid systems.
- Experimental results showed that plasmid-free E. coli could achieve similar product yields of pinoresinol as plasmid-based systems, supporting the viability of this new approach for producing important plant lignans.
Semisynthetic phytochemicals in cancer treatment: a medicinal chemistry perspective.
RSC Med Chem
October 2024
Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab Ghudda Bathinda 151401 India
Cancer is the uncontrolled proliferation of abnormal cells that invade other areas, spread to other organs, and cause metastases, which is the most common cause of death. A review of all FDA-approved new molecular entities (NMEs) shows that natural products and derivatives account for over one-third of all NMEs. Before 1940, unmodified products and derivatives accounted for 43% and 14% of NME registrations, respectively.
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