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Insights from the Construction of Adenovirus-Based Vaccine Candidates against SARS-CoV-2: Expecting the Unexpected.
Viruses
October 2023
Chair of Biochemistry and Molecular Medicine, Center for Biomedical Education and Research (ZBAF), Witten/Herdecke University, Stockumer Str. 10, 58453 Witten, Germany.
To contain the spread of the SARS-CoV-2 pandemic, rapid development of vaccines was required in 2020. Rational design, international efforts, and a lot of hard work yielded the market approval of novel SARS-CoV-2 vaccines based on diverse platforms such as mRNA or adenovirus vectors. The great success of these technologies, in fact, contributed significantly to control the pandemic.
View Article and Find Full Text PDFFuture Interstate Highway System Demands: Predictions Based on Population Projections.
Case Stud Transp Policy
June 2019
Blue Ridge Community College, 180 West Campus Drive, Flat Rock, NC 28731-4728, USA.
The Interstate Highway System (IHS) used to be a symbol of American growth and its economic machine, but the IHS has not been expanded much since its inception. Recently there are both executive and legislative desires to restore and upgrade the IHS to its role as a premier system that can meet the growing and changing demands of the twenty-first century. Demographic forecasting is a precursor to rational transportation planning and decision activities.
View Article and Find Full Text PDFHuntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and beta-cell apoptosis.
Proc Natl Acad Sci U S A
September 2011
Hagedorn Research Institute, 2820 Gentofte, Denmark.
Type 1 diabetes (T1D) is a complex disease characterized by the loss of insulin-secreting β-cells. Although the disease has a strong genetic component, and several loci are known to increase T1D susceptibility risk, only few causal genes have currently been identified. To identify disease-causing genes in T1D, we performed an in silico "phenome-interactome analysis" on a genome-wide linkage scan dataset.
View Article and Find Full Text PDFScaffold/matrix attached region-based nonviral episomal vectors.
Hum Gene Ther
August 2011
Centre for Biomedical Education and Research, Institute of Cell Biology, University Witten/Herdecke, 58453 Witten, Germany.
Because of their high efficiency, virus-based vectors are currently used in most gene therapy trials. Because such vectors bear some potential safety risks, nonviral expression systems could be an attractive alternative. Ideally, these vectors should be completely based on chromosomal elements and replicate as an autonomous unit in the recipient cell, thus avoiding the risk of insertional mutagenesis or immunological reactions of the recipient organism.
View Article and Find Full Text PDFNarrative review: a rational approach to starting insulin therapy.
Ann Intern Med
July 2006
St. Louis University School of Medicine, St. Louis, Missouri, USA.
Background: The emergence of multiple insulin products has provided new opportunities to achieve diabetes control. However, the number of options has raised concerns about the optimal choices of products.
Purpose: To briefly review the pharmacologic characteristics of currently available insulin products and to suggest an initial insulin regimen based on common blood glucose profiles among patients with diabetes.
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