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| http://dx.doi.org/10.1136/adc.37.196.584 | DOI Listing |
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In vitro anti-HIV, cytotoxicity and nutritional analysis of Trianthema portulacastrum L. (Aizoaceae).
BMC Complement Med Ther
January 2024
Department of Horticultural Sciences, Faculty of Applied Sciences, Cape Peninsula University of Technology, Bellville, 7535, South Africa.
The development of antiretroviral therapy has brought a tremendous relief to the world as it minimizes mortality, reduces HIV transmission, and suppresses progression in infected patients. However, the orthodox antiretroviral therapy is faced with limitations which have necessitated a continuous search for more novel plant-based antiviral compounds, which can bypass the existing barriers created by drug resistance and target more viral proteins. Despite the edibility and enormous pharmacological benefits of T.
View Article and Find Full Text PDFEpigenetic Induction of Secondary Metabolites Production in Endophytic Fungi and GC-MS Analysis of Crude Metabolites with Anti-HIV-1 Activity.
Microorganisms
May 2023
HIV Pathogenesis Programme, Doris Duke Medical Research Institute, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.
Article Synopsis
- Sub-Saharan Africa continues to struggle with HIV-1 due to limitations of existing antiretroviral treatments, calling for the need for new inhibitors to combat the virus.
- Researchers cultivated endophytic fungi from a medicinal plant and used sodium butyrate to enhance the production of secondary metabolites, leading to a more potent anti-HIV extract compared to untreated samples.
- Gas chromatography-mass spectrometry analysis revealed that treated fungal extracts contained more bioactive compounds, suggesting that epigenetic modifications can effectively boost the development of potential therapies for HIV-1.
Method Development for Enteric Virus Recovery from Primary Sludge.
Viruses
March 2021
Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, WA 98195, USA.
Enteric viruses, such as poliovirus, are a leading cause of gastroenteritis, which causes 2-3 million deaths annually. Environmental surveillance of wastewater supplements clinical surveillance for monitoring enteric virus circulation. However, while many environmental surveillance methods require liquid samples, some at-risk locations utilize pit latrines with waste characterized by high solids content.
View Article and Find Full Text PDFDecontamination efficacy of sodium hypochlorite solutions for poliovirus.
Biologicals
September 2020
Sanofi Pasteur, 1541 Avenue Marcel Mérieux, 69280, Marcy l'Étoile, France. Electronic address:
Effective decontamination procedures are critical to the successful manufacture and control of poliovirus vaccines to minimize the risk to personnel and the environment. Polio viruses have been reported to be more resistant to disinfectants than many other viruses. We assessed the efficacy of sodium hypochlorite-containing disinfectants for decontamination for three poliovirus serotypes to implement decontamination procedures that are fully compliant with the WHO GAP III and Health authorities' requirements.
View Article and Find Full Text PDFA Review of the Most Commonly Used Methods for Sample Collection in Environmental Surveillance of Poliovirus.
Clin Infect Dis
October 2018
Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Washington.
We performed a review of the environmental surveillance methods commonly used to collect and concentrate poliovirus (PV) from water samples. We compared the sampling approaches (trap vs grab), the process methods (precipitation vs filtration), and the various tools and chemical reagents used to separate PV from other viruses and pathogens in water samples (microporous glass, pads, polyethylene glycol [PEG]/dextran, PEG/sodium chloride, NanoCeram/ViroCap, and ester membranes). The advantages and disadvantages of each method are considered, and the geographical areas where they are currently used are discussed.
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