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Attempted Transmission of Marburg Virus by Bat-Associated Fleas (Ischnopsyllidae: Thaumapsyllinae) to the Egyptian Rousette Bat ().
Viruses
July 2024
Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases of the National Health Laboratory Service, Sandringham 2131, South Africa.
Egyptian rousette bats (ERBs) are implicated as reservoir hosts for Marburg virus (MARV), but natural mechanisms involved in maintenance of MARV in ERB populations remain undefined. A number of hematophagous ectoparasites, including fleas, parasitize bats. Subcutaneous (SC) inoculation of ERBs with MARV consistently results in viremia, suggesting that infectious MARV could be ingested by blood-sucking ectoparasites during feeding.
View Article and Find Full Text PDFMonitoring the VDPV2 outbreak in Egypt during 2020-2021 highlights the crucial role of environmental surveillance and boosting immunization in combating Poliovirus.
BMC Infect Dis
August 2024
Department of Microbiology and Immunology, Faculty of Pharmacy, Organization of African Union, Ain Shams University, St. Abbassia, Cairo, 11566, Egypt.
Background: Poliovirus is a highly infectious enterovirus (EV) that primarily affects children and can lead to lifelong paralysis or even death. Vaccine-derived polioviruses (VDPVs) are a great threat since they are derived from the attenuated virus in the Oral Poliovirus Vaccine (OPV) and can mutate to a more virulent form. The purpose of this study was to identify VDPV serotype 2 through the year 2020-2021 via surveillance of sewage samples collected from different localities and governorates in Egypt and stool specimens from Acute Flaccid Paralysis (AFP) cases.
View Article and Find Full Text PDFAcute Flaccid Myelitis: Mid-Term Clinical Course of Knee Extension Paralysis and Outcomes of Nerve Transfer.
J Bone Joint Surg Am
October 2024
Department of Orthopedic Surgery, Ogori Daiichi General Hospital, Yamaguchi, Japan.
Background: Acute flaccid myelitis (AFM) is a rare debilitating poliomyelitis-like illness characterized by the sudden onset of flaccid palsy in the extremities. The purpose of this study was to report the mid-term clinical course of knee extension in AFM and the effect of contralateral obturator nerve-to-femoral nerve transfer (CONFNT) for restoration of knee extension in AFM.
Methods: Twenty-six patients with lower extremity palsy due to AFM were referred to our clinic for possible surgical reconstruction.
High tibial osteotomy for acute correction and subsequent gradual tensioning of the posterolateral knee ligament complex in treating genu varum combined with a lateral thrust using the Ilizarov technique in adults: surgical technique and early results.
J Orthop Surg Res
June 2023
Orthopaedic Department, Benha University, Benha, Egypt.
Article Synopsis
- This study examines the use of the Ilizarov technique for medial wedge opening high tibial osteotomy (MWOHTO) in 12 adult patients (average age 25.2 years) who have genu varum (bowed legs) and lateral thrust issues.* -
- After a follow-up period averaging 26.3 months, all osteotomies healed successfully, showing significant improvement in knee scores (HSS) and alignment measurements (HKA, MPTA, JLCA), demonstrating the technique's effectiveness.* -
- While some patients experienced mild complications like pin tract infections and pain, the overall outcomes were positive, although two patients had a recurrence of the lateral thrust by the last follow-up.*
Reduced reactogenicity of primary vaccination with DT3aP-HBV-IPV/Hib compared with DT2aP-HBV-IPV-Hib among infants: Mathematical projections in six countries.
Hum Vaccin Immunother
December 2023
GSK, Singapore, Singapore.
The hexavalent vaccines DT3aP-HBV-IPV/Hib and DT2aP-HBV-IPV-Hib are routinely used for primary immunization of infants against diphtheria, tetanus, pertussis, hepatitis B virus, poliomyelitis, and type b. A recent publication showed that after primary immunization with these vaccines, the odds ratios of adverse reactions (ARs) were significantly lower for DT3aP-HBV-IPV/Hib than for DT2aP-HBV-IPV-Hib. Our aim is to understand the impact of the various reactogenicity profiles at country level by comparing the ARs induced by one dose of DT3aP-HBV-IPV/Hib versus DT2aP-HBV-IPV-Hib in the primary infant immunization course.
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