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First reported case of multiple endocrine neoplasia type 1 in an Australian Aboriginal.
Endocrinol Diabetes Metab Case Rep
July 2024
Alice Springs Hospital, Alice Springs, Northern Territory, Australia.
Article Synopsis
- - The case study discusses a 48-year-old Aboriginal Australian woman diagnosed with Multiple Endocrine Neoplasia type 1 (MEN1), who faced significant health issues including hypercalcaemia, following a history of parathyroid surgery and several severe medical conditions, indicating the complexity of her case.
- - Genetic testing revealed a rare variant in the MEN1 gene, but cultural and logistical challenges hindered effective genetic counseling for her family, highlighting gaps in healthcare support for remote Aboriginal communities.
- - The case underscores the critical need for improved genetic counseling approaches and timely recognition of rare diseases in remote areas, as late diagnoses can lead to severe health consequences, as seen in her unfortunate passing in 2021.
Modern Management of Gastric Neuroendocrine Neoplasms.
Curr Treat Options Oncol
September 2024
Department of Medicine, Section of Medical Oncology, Yale School of Medicine, 25 York Street, New Haven, CT, 06510, USA.
Gastric neuroendocrine neoplasms (G-NENs) are a heterogeneous group of tumors that broadly fall into two groups. The first group, driven by oversecretion of gastrin, are generally multifocal, small, and behave indolently with a low (but non-zero) risk of progression and metastatic spread. They are conventionally categorized into type 1, with endogenous gastric-based overproduction of gastrin, and type 2 G-NEN, with overproduction of gastrin from an extra-gastric gastrin-secreting tumor.
View Article and Find Full Text PDFLong-Term Proton Pump Inhibitor-Acid Suppressive Treatment Can Cause Vitamin B Deficiency in Zollinger-Ellison Syndrome (ZES) Patients.
Int J Mol Sci
July 2024
Digestive Diseases Branch, NIDDK, NIH, Bethesda, MD 20892-1804, USA.
Article Synopsis
- * A study of 175 ZES patients showed that 21% had vitamin B deficiency after an average of 10.2 years of treatment, particularly correlating with extremely low acid control rates.
- * The findings indicate that chronic PPI use results in significant acid reduction, which negatively impacts vitamin B levels and body stores, increasing the risk of deficiency.
Presentation, Diagnosis, and Treatment of a Sporadic Gastrinoma With Liver Metastases.
Cureus
May 2024
General Surgery, Brookdale University Hospital Medical Center, Brooklyn, USA.
Article Synopsis
- - A gastrinoma is a rare but serious tumor that produces gastrin, which can cause symptoms like anemia, weight loss, and diarrhea, complicating early detection.
- - These tumors often spread to the liver, and surgery is typically necessary to remove both the primary tumor and any metastases for a chance at a cure.
- - This report discusses a case involving a 59-year-old woman with anemia and gastrointestinal bleeding, revealing a pancreatic gastrinoma with extensive liver metastases, along with the treatment approach taken to improve her survival odds.
Natural language processing assisted detection of inappropriate proton pump inhibitor use in adult hospitalised patients.
Eur J Hosp Pharm
June 2024
Department of Electronic Engineering, Tsinghua University, Beijing, China
Article Synopsis
- The study aimed to create a system (PPI-MS) that monitors the clinical use of proton pump inhibitors (PPIs) in hospitalized adults, enhancing the detection of inappropriate usage.
- Researchers used natural language processing to analyze patient records and identify both therapeutic and preventive applications of PPIs, reviewing 9421 cases from July 2022 to July 2023.
- Results showed that over 50% of PPIs were used for prophylaxis, with nearly half deemed inappropriate, mainly due to lack of indications, and the monitoring system demonstrated a high accuracy and efficiency compared to manual tracking methods.
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