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Atropine stereotypy and its inhibition by intracaudate triperidol in the rat.
Pol J Pharmacol Pharm
March 1980
One component (rearing) of the stereotyped behavior of the rat was quantitated using erigometer, a new device developed in this laboratory. Intraperitoneal injection of atropine, but not methylatropine, caused dose-related stereotyped behavior in the rat and this effect was antagonized by intracaudate injection of triperidol in a dose-related manner. It is concluded that stereotypy can be evoked also in the case when the striatal dopaminergic tone is normal or even below normal: it is the equilibrium of the striatal cholinergic-dopaminergic systems which must be shifted towards dopamine, which is necessary for the development of this behavioral manifestation.
View Article and Find Full Text PDFPsychotropic drugs as potential antitumor agents: a selective screening study.
Cancer Treat Rep
January 1978
Compounds with known psychotropic properties were tested for activity in murine ip L1210 leukemia and B 16 melanoma in a protocol designed to obtain leads for new antitumor agents which might also possess central nervous system (CNS) antitumor properties. Barbiturates and hallucinogenic compounds were the only compound types deliberately excluded. Representatives from most of the other known CNS agent classes were included among the 297 psychotropic drugs evaluated.
View Article and Find Full Text PDF[Neuroleptic long term care with extremely low doses in psychotic syndromes of paranoid-hallucination type].
Psychiatr Neurol Med Psychol Beih
February 1978
About 30 patients with, in some cases, recurring paranoid or paranoid-hallucinatory psychoses underwent a long-term treatment--from 2--6 years according to individual cases--with very small doses of powerful neuroleptics (Haloperidol, Triperidol, and occasionally Trisedyl). Relapses, such as remanifestations, which occured in some cases, were easily controlled either in outpatients or in the day clinic. No extrapyramidal symptoms of pharmacogenic defect syndromes were observed.
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