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Crystal structure of di-μ-acetato-κ :-bis{(acetato-κ ,')tetra-aqua-[1-(pyridin-2-yl-methylidene-κ)-2-(pyridin-2-yl-κ)hydrazine-κ ]lanthanum(III)} dinitrate hemihydrate.
Acta Crystallogr E Crystallogr Commun
January 2025
Département de Chimie Faculté des Sciences et Techniques Université Cheik Anta Diop Dakar Senegal.
In the binuclear title complex, [La(CHO)(CHN)(HO)](NO)·0.5HO, the two lanthanum ions are nine coordinate in a distorted trigonal-prismatic geometry. Each La ion is bonded to three N atoms of the Schiff base, 1-(pyridin-2-yl)-2-(pyridin-2-yl-methyl-ene)hydrazine and is coordinated by one acetate group, which acts in -bidentate mode and two acetate groups that act in -mode between the two La ions.
View Article and Find Full Text PDFNew semisynthetic α-glucosidase inhibitor from a doubly-chemically engineered extract.
Nat Prod Bioprospect
January 2025
Consejo Nacional de Investigaciones Científicas y Técnicas, Suipacha 531, S2002LRK, Rosario, Argentina.
Chemically engineered extracts represent a promising source of new bioactive semi-synthetic molecules. Prepared through direct derivatization of natural extracts, they can include constituents enriched with elements and sub-structures that are less common in natural products compared to drugs. Fourteen such extracts were prepared through sequential reactions with hydrazine and a fluorinating reagent, and their α-glucosidase inhibition properties were compared.
View Article and Find Full Text PDFAnamorelin and Conduction Defects: A Literature Review and Analysis of the Japanese Pharmacovigilance Database.
In Vivo
December 2024
Department of Practical Pharmacy, Nihon Pharmaceutical University, Saitama, Japan
Background/aim: Cancer cachexia is characterized by weight loss with a specific decrease in skeletal muscle and adipose tissue. In Japan, anamorelin, which has a novel mechanism of action, was approved in 2021 for the treatment of cancer cachexia. However, little information is available on its safety in routine clinical care, in particular the occurrence of conduction defects as adverse reactions.
View Article and Find Full Text PDFA sensitive bromate sensor based on a gold nanoparticle-poly(diallyldimethylammonium chloride)-reduced graphene oxide nanocomposite modified glassy carbon electrode.
Mikrochim Acta
December 2024
College of Chemistry and Chemical Engineering, Yan'an University, Yan'an, 716000, Shaanxi, China.
A nanocomposite consisting of gold nanoparticles (AuNPs), poly(diallyldimethylammonium chloride) (PDDA), and reduced graphene oxide (rGO) was fabricated by a two-step chemical reduction method. Firstly, a PDDA-rGO composite was prepared by using hydrazine hydrate as a reducing agent. Subsequently, the AuNP-PDDA-rGO composite was prepared in ethylene glycol with PDDA-rGO and HAuCl as raw materials using sodium citrate as a reduction agent.
View Article and Find Full Text PDFSynthesis and Structure-Activity Relationship (SAR) Studies on New 4-Aminoquinoline-Hydrazones and Isatin Hybrids as Promising Antibacterial Agents.
Molecules
December 2024
Medicinal Chemistry Laboratory, Department of Biosciences, Jamia Millia Islamia, New Delhi 110025, India.
In response to the escalating crisis of antimicrobial resistance (AMR), there is an urgent need to research and develop novel antibiotics. This study presents the synthesis and assessment of innovative 4-aminoquinoline-benzohydrazide-based molecular hybrids bearing aryl aldehydes () and substituted isatin warheads (), characterized using multispectroscopic techniques with high purity confirmed by HRMS. The compounds were evaluated against a panel of clinically relevant antibacterial strains including the Gram-positive , , and and a Gram-negative bacterial strain.
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