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[Analysis of acute and chronic effects of antidepressive agents in a learned helplessness model in mice].
Biull Eksp Biol Med
November 1983
In experimental learned helplessness in mice determined by preliminary inavoidable aversive exposure, activity of tricyclic antidepressants (desipramine, chlorimipramine, amitryptyline), type A MAO inhibitors (pyrazidol), and atypical (zimelidine, trazodon, befuralin) antidepressants as well as that of potential antidepressants (LIS-30, DZK-153) were determined upon chronic administration. The tricyclic compounds, befuralin and DZK-153 removed learned helplessness only after 14 days of administration. The substances with a predominant serotoninomimetic action (zimelidin, trazodon in high doses, pyrazidol, LIS-30) showed high efficacy following 6 days of administration.
View Article and Find Full Text PDFAfter placing rats or mice into the cylinders filled with water the animals after initial period active swimming, take the immobilization position the time of which is minimized by administering antidepressants. Experiments were made with random-bred, tetrahybrids CBWA, and C57BL/6, BALB/c, CBA, F1 CBA/c55BL mice. Tetrahybrids CBWA appeared to be an optimal species for making experiments.
View Article and Find Full Text PDFThe learned helplessness model of depression was tested for its responsiveness to several types of antidepressant therapies, and to a number of psychoactive drugs which are not effective in treating depression in humans. Chronic administration of tricyclic antidepressants (imipramine, desipramine, amitryptyline, nortryptyline, or doxepin), atypical antidepressants (iprindole or mianserin), monoamine oxidase inhibitors (iproniazid or pargyline), or electroconvulsive shock was effective in reversing learned helplessness. Chronic treatment with anxiolytics (diazepam, lorazepam, or chlordiazepoxide), neuroleptics (chlorpromazine or haloperidol) stimulants (amphetamine or caffeine), or depressants (phenobarbital or ethanol) was not.
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