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ESAT-6 protein suppresses allograft rejection by inducing CD4Foxp3 regulatory T cells through IκBα/cRel pathway.
Front Immunol
January 2025
Section of Immunology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Background: Maintenance immunosuppression is required for suppression of alloimmunity or allograft rejection. However, continuous use of immunosuppressants may lead to various side effects, necessitating the use of alternative immunosuppressive drugs. The early secreted antigenic target of 6 kDa (ESAT-6) is a virulence factor and immunoregulatory protein of mycobacterium tuberculosis (Mtb), which alters host immunity through dually regulating development or activation of various immune cells.
View Article and Find Full Text PDFTotal Pancreatectomy for Locally Advanced Pancreatic Adenocarcinoma with Coeliac Trunk Resection and Retrograde Gastric Revascularization Through Aorto-Hepato-Spleno Allograft.
Ann Surg Oncol
January 2025
Department of HPB Surgery and Liver Transplantation, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris (AP-HP), Université de Paris-Cité, Clichy, France.
Background: Locally advanced pancreatic adenocarcinomas (LA-PDAC) are more frequently operated now than in the past because of new regimen chemotherapy and improvement in surgical technique. Resection of the coeliac trunk (CT) during pancreatoduodenectomy (PD) or total pancreatectomy (TP) is not routinely done owing to the risk of liver and gastric ischaemia. In this video, a patient with LA-PDAC underwent TP with CT resection and retrograde gastric revascularization through the distal splenic artery.
View Article and Find Full Text PDFNavigating 'grey areas' and challenges during evaluation of transplant eligibility in specific myelofibrosis populations: a perspective on behalf of the Chronic Malignancies Working Party of the EBMT.
Bone Marrow Transplant
January 2025
Department of Haematology and Stem Cell transplantation, University College London Hospitals NHS Foundation Trust, London, UK.
Significant efforts have been made to effectively select myelofibrosis (MF) patients who can benefit from allogeneic hematopoietic cell transplantation (allo-HCT), the only current cure for MF. The recent EBMT/ELN 2024 recommendations offer valuable guidance for hematologists and transplant physicians. However, several grey areas remain in day-to-day clinical practice regarding the feasibility and optimal preparation for transplantation in patients with this disease.
View Article and Find Full Text PDFEndometrial regeneration cell-derived exosomes loaded with siSLAMF6 inhibit cardiac allograft rejection through the suppression of desialylation modification.
Cell Mol Biol Lett
October 2024
Department of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.
Article Synopsis
- Acute transplant rejection is a major challenge in organ transplantation, and this study investigates the potential of endometrial regenerative cell-derived exosomes (ERC-Exos) to mitigate this issue by targeting a specific immune-regulating molecule, SLAMF6.
- The experimental results showed that treatment with ERC-Exos containing siSLAMF6 led to longer survival of transplanted organs in mice, altered cytokine profiles in the serum, and reduced the activation of harmful T cells.
- This research suggests that ERC-Exos can effectively modify immune responses by promoting the differentiation of regulatory T cells while inhibiting the proliferation of Th1 and Th17 cells, which are associated with transplant rejection.
Fetal bone engraftment reconstitutes the immune system in pigs with severe combined immunodeficiency.
Lab Anim (NY)
October 2024
Division of Animal Science, College of Agriculture Food and Natural Resources, University of Missouri, Columbia, MO, USA.
Article Synopsis
- Scientists have genetically modified pigs to have a condition called severe combined immunodeficiency (SCID), which makes them have weak immune systems and shorter lifespans.
- These SCID pigs are useful for research on how the immune system works and can help study diseases.
- A new method was tested where the immune systems of SCID piglets were improved by transplanting fetal bone, leading to healthier pigs that lived longer and could grow normally, which is great for future studies.
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