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Distinct relative abundances in pathogens detected in mechanically ventilated patients with suspected pneumonia in the intensive care unit at King Abdulaziz University Hospital.
Sci Rep
January 2025
Department of Biological Sciences, Faculty of Science, King AbdulAziz University, Jeddah, Saudi Arabia.
In this study, we present for the first time the landscape of the lung microbiota in patients with ventilator-associated pneumonia in Intensive Care Units in Saudi Arabia. DNA from 83 deep endotracheal aspirate lung samples was subjected to PacBio sequencing to identify pathogens in comparison with conventional diagnostic techniques. Patients on ventilation with pneumonia presented with similar lung flora to those of patients on ventilation without pneumonia.
View Article and Find Full Text PDFCombined Multilayered Amniotic Membrane Graft and Fibrin Glue as a Surgical Management of Limbal Dermoid Cyst.
J Clin Med
January 2025
Ophthalmology Section, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy.
To report the cosmetic, clinical, and visual outcomes of a combined surgical approach for treating a corneal/limbal dermoid using excision and a three-layered amniotic membrane graft with fibrin glue. An 18-year-old female presented with impaired vision and ocular discomfort caused by a prominent dome-shaped limbal congenital dermoid on the inferotemporal cornea, resulting in a significant aesthetic concern. A full assessment, including refraction, best-corrected visual acuity (BCVA), corneal topography, aberrometry and anterior segment OCT (AS-OCT) was conducted to plan the surgical approach.
View Article and Find Full Text PDFMicrobial Colonization and Antibiotic Resistance Profiles in Chronic Wounds: A Comparative Study of Hidradenitis Suppurativa and Venous Ulcers.
Antibiotics (Basel)
January 2025
Department of Dermatovenerology, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
: Chronic wounds, including hidradenitis suppurativa (HS) and venous ulcers (VU), are commonly associated with complex microbial communities that may influence wound healing and treatment outcomes. Understanding microbial diversity and antibiotic resistance patterns is essential in order to optimize therapeutic strategies. This study aimed to investigate the microbial populations and antibiotic resistance profiles in HS and VU patients, comparing the prevalence of common pathogens and their antimicrobial resistance profiles.
View Article and Find Full Text PDFRecurrent Urinary Tract Infections (UTIs): A Review and Proposal for Clinicians.
Antibiotics (Basel)
January 2025
Department of Anesthesia and Intensive Care Unit, ULSS6 Euganea, 35013 Cittadella, Padova, Italy.
The pathogenesis of recurrent urinary tract infections (rUTIs), a common problem in the female population, is becoming better understood following recent studies of bacterial persistence and intracellular bacterial communities. Incorporating these new insights, we propose pulsed antibiotic therapy with intracellular activity as a possible treatment for rUTIs.
View Article and Find Full Text PDFSuggested Dosing of Select Beta-lactam Agents for the Treatment of Antimicrobial-Resistant Gram-Negative Infections in Children.
J Pediatric Infect Dis Soc
January 2025
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Background: The Infectious Diseases Society of America (IDSA) publishes annual guidance on the treatment of antimicrobial-resistant (AMR) gram-negative infections. Within the AMR guidance, suggested dosages of antibiotics for adults infected with AMR pathogens are provided. This document serves as a companion document to the IDSA guidance to assist pediatric specialists with dosing β-lactam agents for the treatment of AMR infections in children.
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