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Amino Acid Patterns in Children with Autistic Spectrum Disorder: A Preliminary Biochemical Evaluation.
Nutrients
January 2025
Department of Pediatrics, Buzzi Children's Hospital, 20154 Milan, Italy.
Background: The metabolism of plasma amino acid (AA) in children with autism spectrum disorder (ASD) has been extensively investigated, yielding inconclusive results. This study aims to characterize the metabolic alterations in AA profiles among early-diagnosed children with ASD and compare the findings with those from non-ASD children.
Methods: We analyzed plasma AA profiles, measured by ion exchange chromatography, from 1242 ASD children (median age = 4 years; 81% male).
Effect of menopause on circulating amino acid concentrations in women with fibromyalgia and healthy women.
Maturitas
February 2025
Instituto de Investigación Biosanitaria ibs.GRANADA, 18012 Granada, Spain; Department of Physical Therapy, Faculty of Health Sciences, University of Granada, Avenida de la Ilustración, 60, 18016 Granada, Spain. Electronic address:
Objectives: Fibromyalgia is a complex syndrome that appears more frequently during menopause. No previous studies have investigated the effect of menopause on amino acids in women with fibromyalgia. Therefore, we have examined serum amino acid concentrations in premenopausal and postmenopausal women with fibromyalgia and healthy women.
View Article and Find Full Text PDFMetabolic Analysis of Three-Dimensional Cultured Gastrointestinal Cancer Cells Suggests that l -Arginine Inhibits Tumor Growth by Affecting the Urea Cycle.
Pathobiology
December 2024
Division of Human Pathology, Department of Pathology, Shiga University of Medical Science, Otsu, Japan.
Introduction: There is evidence for the anticancer effects of
Methods: Various upper gastrointestinal cancer cells (OE19, OE33, MKN1, MKN45, MKN74, and AGS) were divided into arginine-treated and -untreated groups and cultured using two-dimensional and three-dimensional culture systems. Proliferation was evaluated using the MTT assay to identify arginine-sensitive (OE33) and arginine-insensitive (OE19) strains.
Assessment of the Relationship Between Amino Acid Status and Parkinson's Disease: A Comprehensive Review and Meta-analysis.
Can J Neurol Sci
December 2024
Interdisciplinary Food Metabolism and Clinical Nutrition Department, Ankara University, Institute of Health Sciences, Ankara, Turkey.
Background: Parkinson's disease (PD) is characterized by the inability of dopamine production from amino acids. Therefore, changes in amino acid profile in PD patients are very critical for understanding disease development. Determination of amino acid levels in PD patients with a cumulative approach may enlighten the disease pathophysiology.
View Article and Find Full Text PDFThe role of urine metabolomics in the diagnosis and management of adult and pediatric Crohn's disease and ulcerative colitis.
Biomarkers
December 2024
Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.
Introduction: Urine metabolomics offers a non-invasive approach to diagnose and manage inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), by identifying distinct metabolic signatures.
Objectives: This narrative review summarizes current findings on urinary metabolites in IBD, evaluating their roles in disease differentiation, assessment of activity, and monitoring therapeutic response.
Methods: A comprehensive literature search of PubMed and MEDLINE up to October 2023 was conducted using keywords, such as 'urine metabolomics', 'inflammatory bowel disease', 'Crohn's disease', 'ulcerative colitis', and 'urinary biomarkers'.
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