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Technology and Dementia Preconference.
Alzheimers Dement
December 2024
National University of Singapore, Singapore, Singapore.
Background: Identifying language variation in healthy aging speakers is important for understanding normal cognitive aging. Setting a baseline of normal aging languages in the first place is necessary for the evaluation of language performances of old adults. Lexical concreteness, a well-studied psycholinguistic parameter, has been used to detect semantic memory-related deficits.
View Article and Find Full Text PDFLately, important advancements in visualizing RNAs in fixed and live cells have been achieved. While mRNA imaging techniques are well-established, the development of effective methods for studying non-coding RNAs (ncRNAs) in living cells are still challenging but necessary, as they show a variety of functions and intracellular localizations, including participation in highly dynamic processes like phase-transition, which is still poorly studied in vivo. Addressing this issue, we tagged two exemplary ncRNAs with the fluorescent RNA (fRNA) Pepper.
View Article and Find Full Text PDFArtificially tagging tumors with nano-aluminum adjuvant-tethered antigen mRNA recruits and activates antigen-specific cytotoxic T cells for enhanced cancer immunotherapy.
Biomaterials
January 2025
Institute of Systems and Physical Biology, Shenzhen Bay Laboratory, Shenzhen, 518107, China; School of Medicine, Hangzhou City University, Hangzhou, 310015, China; Guoke Ningbo Life Science and Health Industry Research Institute, Ningbo, 315040, China. Electronic address:
T cell therapy for solid tumors faces significant challenges due to the immune off-target attack caused by the loss of tumor surface antigens and inactivation in acidic tumor microenvironment (TME). Herein, we developed a bifunctional immunomodulator (MO@NAL) by loading ovalbumin (OVA; model antigen) mRNA (mOVA) onto lysozyme-coated layered double hydroxide nano-aluminum adjuvant (NA). The NA's inherent alkalinity effectively neutralizes the excess acid within the TME and suppresses regulatory T cells, creating a favorable microenvironment to enhance cytotoxic T cell infiltration and activation in tumors.
View Article and Find Full Text PDFApplication of Conservation Genomics to Investigate the Role of Pathogens on the Migration of Sea-Run Brown Trout (Salmo trutta).
J Fish Dis
January 2025
Laboratory for Freshwater Ecology and Inland Fisheries, NORCE Norwegian Research Centre, Bergen, Norway.
Pathogens play a key role in individual function and the dynamics of wild populations, but the link between pathogens and individual performance has rarely been investigated in the wild. Migrating salmonids offer an ideal study system to investigate how infection with pathogens affects performance given that climate change and fish farming portend increasing prevalence of pathogens in wild populations. To test for effects of pathogen burden on the performance of a migrating salmonid, we paired data from individual brown trout tagged with acoustic accelerometer transmitters and gill biopsies to investigate how pathogen infection affected whole animal activity during the spawning migration.
View Article and Find Full Text PDFInduced cell phenotype activity recording of DNA-tagged ligands.
RSC Chem Biol
December 2024
Department of Chemistry, The Scripps Research Institute 10550 North Torrey Pines Road La Jolla CA 92037 USA
Based on their ability to canvas vast genetic or chemical space at low cost and high speed, DNA-encoded libraries (DEL) have served to enable both genomic and small molecule discovery. Current DEL chemical library screening approaches focus primarily on target-based affinity or activity. Here we describe an approach to record the phenotype-based activity of DNA-encoded small molecules on their cognate barcode in living cells.
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