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The gut microbiota predicts and time-restricted feeding delays experimental colitis.
Gut Microbes
December 2025
Department of Microbiome Research and Applied Bioinformatics, Institute for Nutritional Sciences, University of Hohenheim, Stuttgart, Germany.
The etiology of inflammatory bowel disease (IBD) remains unclear, treatment options unsatisfactory and disease development difficult to predict for individual patients. Dysbiosis of the gastrointestinal microbiota and disruption of the biological clock have been implicated and studied as diagnostic and therapeutic targets. Here, we examine the relationship of IBD to biological clock and gut microbiota by using the IL-10 deficient () mouse model for microbiota-dependent spontaneous colitis in combination with altered (4 h/4 h) light/dark cycles to disrupt and time-restricted feeding (TRF) to restore circadian rhythmicity.
View Article and Find Full Text PDFChemoprotective Potential of Cyanidin-3-Glucoside Against 1,2-Dimethylhydrazine-Induced Colorectal Cancer: Modulation of NF-κB and Bcl-2/Bax/Caspase Pathway.
J Biochem Mol Toxicol
February 2025
Department of Gastroenterology, The Second Hospital of Heilongjiang Province, Harbin City, Heilongjiang Province, China.
Colorectal cancer (CRC) represents a significant global health challenge, with approximately 1.8 million new cases diagnosed annually and a mortality toll exceeding 881,000 lives each year. This study aimed to evaluate the chemoprotective efficacy of Cyanidin-3-glucoside (C3G) in a rat model of CRC induced by 1,2-dimethylhydrazine (DMH).
View Article and Find Full Text PDFExperimental Test of Perceptions of Psychedelics by Therapeutic and Recreational Use.
J Psychoactive Drugs
January 2025
Department of Psychology, Washington State University Vancouver, Vancouver, WA, USA.
Recent research on the potential therapeutic value of psychedelic substances has led to changes in media representation and drug policy in some U.S. states.
View Article and Find Full Text PDFThe conformational landscape of human transthyretin revealed by cryo-EM.
Nat Struct Mol Biol
January 2025
Department of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA, USA.
Transthyretin (TTR) is a natively tetrameric thyroxine transporter in blood and cerebrospinal fluid whose misfolding and aggregation causes TTR amyloidosis. A rational drug design campaign identified the small molecule tafamidis (Vyndamax) as a stabilizer of the native TTR fold, and this aggregation inhibitor is regulatory agency approved for the treatment of TTR amyloidosis. Here we used cryo-EM to investigate the conformational landscape of this 55 kDa tetramer in the absence and presence of one or two ligands, revealing inherent asymmetries in the tetrameric architecture and previously unobserved conformational states.
View Article and Find Full Text PDFExploration of the Evidence on Discharge From Hospital to Home for Children With Medical Complexity and Their Parents: A Review of the Literature.
Child Care Health Dev
January 2025
School of Nursing, Trinity Western University, Langley, British Columbia, Canada.
Background: Children with medical complexity (CMC) require complex care that parents must independently provide and manage when discharged home from hospital. It is important that parents are adequately prepared to safely transition home from hospital with their child.
Method: A synthesis of findings from research articles was conducted to map and summarize available evidence on CMC and their parents' experiences of discharge from hospital to home.
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