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Article Synopsis
  • Ventricular arrhythmias (VAs) are uncommon but can occur after electrical cardioversion (ECV) for atrial fibrillation (AF), with an incidence of about 0.2% based on a study of nearly 12,000 ECV procedures.
  • The study involved 23 patients who experienced VAs within 10 days of ECV, with most cases developing 28.5 hours after the procedure, and a significant number had underlying health issues like congestive heart failure.
  • The findings suggest that while VAs post-ECV are rare, they can be life-threatening, especially in patients with certain risk factors, indicating that careful monitoring is essential for these individuals.
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Clofazimine and QT prolongation in the treatment of rifampicin-resistant tuberculosis: Findings of aDSM in Taiwan.

J Microbiol Immunol Infect

October 2024

Division of Pulmonary Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, 111 Hsin-Long Road, Section 3, Taipei City, 116, Taiwan; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, 250 Wuxing Street, Xinyi District, Taipei City, 110, Taiwan; International Union Against Tuberculosis and Lung Disease, 2 Rue Jean Lantier, 75001, Paris, France. Electronic address:

Background: Bedaquiline, delamanid and fluoroquinolones are associated with increased QTcF. Whether clofazimine is associated with QTcF prolongation is less clear.

Methods: All patients with rifampicin-resistant TB enrolled between May 2017 and Dec 2019 were included.

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Introduction: The rising prevalence of psychiatric disorders has resulted in a significant increase in the use of antipsychotic medications. These agents may prolong the corrected QT interval (QTc), running the risk of precipitating ventricular arrhythmias, notably Torsades de Pointes (TdP). Current recommendations vary regarding the optimal approach to safe prescribing practices and QTc surveillance for antipsychotics.

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The clinical manifestations of licorice-induced pseudoaldosteronism include muscle weakness, periodic paralysis, hypokalemia, and hypertension. Excessive licorice consumption can lead to adverse reactions affecting multiple systems, including the endocrine, cardiovascular, nervous, digestive, and immune systems. Although licorice is a frequently used Chinese herbal medicine, life-threatening adverse reactions have been reported among its users.

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Article Synopsis
  • The study investigates adverse drug reactions (ADRs) for metoclopramide and prucalopride, both used for gastrointestinal issues, using the FDA's Adverse Event Reporting System (FAERS) data from January 2013 to December 2023.
  • Key ADRs for metoclopramide include tardive dyskinesia (36.2%), dystonia (15.7%), and serious heart risks like Torsade de pointes, while prucalopride commonly causes headaches (13.9%), diarrhea (13.4%), and abdominal pain (11.6%).
  • The findings suggest that both drugs carry significant risks for serious side effects, with metoclop
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