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The influence of sodium-glucose co-transporter-2 inhibitors on the risk of cancer therapy-related cardiac dysfunction: A meta-analysis.
Biomol Biomed
March 2025
Department of Clinical Nutrition, Chongqing Jiangjin District Central Hospital/Chongqing University Affiliated Jiangjin Hospital, Chongqing, China.
Cancer therapy-related cardiac dysfunction (CTRCD) is a major concern for patients undergoing cardiotoxic cancer treatments. Sodium-glucose co-transporter-2 (SGLT2) inhibitors have shown cardioprotective effects in both diabetic and non-diabetic populations. However, their impact on CTRCD risk remains uncertain.
View Article and Find Full Text PDFRegulation of the immune microenvironment by SUMO in diabetes mellitus.
Front Immunol
March 2025
Department of Endocrinology and Metabolism, Jiujiang Hospital of Traditional Chinese Medicine, Jiujiang, Jiangxi, China.
Post-translational modifications such as SUMOylation are crucial for the functionality and signal transduction of a diverse array of proteins. Analogous to ubiquitination, SUMOylation has garnered significant attention from researchers and has been implicated in the pathogenesis of various human diseases in recent years, such as cancer, neurological lesions, cardiovascular diseases, diabetes mellitus, and so on. The pathogenesis of diabetes, particularly type 1 and type 2 diabetes, has been closely associated with immune dysfunction, which constitutes the primary focus of this review.
View Article and Find Full Text PDFBackground And Aims: The primary objective of glycemic control in individuals with diabetes mellitus is to avert or postpone complications, which ultimately leads to an improved quality of life. Nonetheless, achieving the recommended targets for glycemic control in clinical settings often proves challenging. Consequently, it is crucial to ascertain factors that affect glycemic outcomes to enhance the management of diabetes mellitus.
View Article and Find Full Text PDFThe Effect of 50% Dextrose on Serum Glucose Levels in Adult Hypoglycemic Patients: A Prospective Observational Study.
Cureus
March 2025
Emergency Medicine, Nizwa Hospital, Nizwa, OMN.
Objective: This study aimed to observe changes in serum glucose levels following the administration of 50 mL of 50% dextrose solution (D50) in hypoglycemic patients. Specifically, we seek to determine the prevalence of rebound hyperglycemia episodes, the peak effect, and the duration of action of a single dose of 50 mL D50.
Method: This prospective observational study was conducted at four emergency departments (two tertiary care hospitals and two secondary care hospitals) in Oman over a three-year period, from May 1, 2019, to April 30, 2022.
Multimorbidity characteristics in older adults and their associated factors in complex networks: a cross-sectional study.
Front Public Health
March 2025
Department of Medical Quality Management, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Background: Multimorbidity of chronic diseases has become an increasingly serious public health problem. However, the research on the current situation of multimorbidity in the older adults in Jiangsu, China is relatively lacking.
Methods: We surveyed a total of 229,926 inpatients aged above 60 and with two or more chronic diseases in the First Affiliated Hospital with Nanjing Medical University from January 1, 2015 to December 31, 2021.
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