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Proteomic Analyses in COVID-19-Associated Secondary Hemophagocytic Lymphohistiocytosis.
Crit Care Explor
February 2025
Center for Fundamental Immunology, Benaroya Research Institute, Seattle, WA.
Context: COVID-19 has been associated with features of a cytokine storm syndrome with some patients sharing features with the hyperinflammatory disorder, secondary hemophagocytic lymphohistiocytosis (sHLH).
Hypothesis: We hypothesized that proteins associated with sHLH from other causes will be associated with COVID-sHLH and that subjects with fatal COVID-sHLH would have defects in immune-related pathways.
Methods And Models: We identified two cohorts of adult patients presenting with COVID-19 at two tertiary care hospitals in Seattle, Washington in 2020 and 2021.
Magnesium phosphates experienced high-temperature transition found on the CI-like carbonaceous chondrite Yamato 980115 by Raman microspectroscopy.
Anal Sci
January 2025
National Institute of Polar Research (NIPR), 10-3 Midori-Cho, Tachikawa, Tokyo, 190-8518, Japan.
Magnesium phosphate grains, minor accessory minerals found on the primitive meteorite Yamato 980115 (Y 980115), were investigated by Raman microspectroscopy. All magnesium phosphate grains found in the present study can be assigned to farringtonite, dehydrated magnesium phosphate Mg(PO)-I. Since the Mg(PO)-I is generally formed via the irreversible thermal transition from the polymorphs of Mg(PO)-II and -III at above 750-800 degree Celsius, we can infer that the parent body of the Y 980115 meteorites experienced thermal alteration with such a high temperature.
View Article and Find Full Text PDFStem Cell Therapy Modulates Molecular Cues of Vasogenic Edema Following Ischemic Stroke: Role of Sirtuin-1 in Regulating Aquaporin-4 Expression.
Stem Cell Rev Rep
January 2025
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, India.
Background: Conventional post-stroke edema management strategies are limitedly successful as in multiple cases of hemorrhagic transformation is being reported. Clinically, acute-ischemic-stroke (AIS) intervention by endovascular mesenchymal stem cells (MSCs) have shown benefits by altering various signaling pathways. Our previous studies have reported that intra-arterial administration of 1*10 MSCs (IA-MSCs) were beneficial in alleviating post-stroke edema by modulating PKCδ/MMP9/AQP4 axis and helpful in preserving the integrity of blood-brain-barrier (BBB).
View Article and Find Full Text PDFDevelopmental functional brain network abnormalities in autism spectrum disorder comorbid with attention deficit hyperactivity disorder.
Eur J Pediatr
January 2025
Department of Developmental and Behavioral Pediatrics, Children's Medical Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Unlabelled: Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) often co-occur. Developmental stages significantly influence the variations in brain alterations. However, whether ASD comorbid with ADHD (ASD + ADHD) represents a unique neural characteristic from ASD without comorbid ADHD (ASD-alone), or instead manifests a shared neural correlate associated with ASD across diverse age cohorts remain unclear.
View Article and Find Full Text PDFImpact of Fermented Milk On Gut Microbiota And Human Health: A Comprehensive Review.
Curr Microbiol
January 2025
Dairy Department, National Research Centre, Dokki, Cairo, Egypt.
The beneficial impact of gut microbiota on human health has encouraged studies on factors modulating it. Among the different factors, diet plays a vital role in this area. Many studies on animals and humans have been concerned with the effects of fermented milk products on gut microbiota and how they relate to health benefits.
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