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Proteostasis and metabolic dysfunction characterize a subset of storage-induced senescent erythrocytes targeted for post-transfusion clearance.
J Clin Invest
March 2025
INSERM, BIGR, Université Paris Cité, Paris, France.
Although refrigerated storage slows the metabolism of volunteer donor RBCs, which is essential in transfusion medicine, cellular aging still occurs throughout this in vitro process. Storage-induced microerythrocytes (SMEs) are morphologically-altered senescent RBCs that accumulate during storage and are cleared from circulation following transfusion. However, the molecular and cellular alterations that trigger clearance of this RBC subset remain to be identified.
View Article and Find Full Text PDFImpact of Preschool Hearing Screening in Low-Income Communities: Program Outcomes and Caregiver Perspectives.
Lang Speech Hear Serv Sch
March 2025
Department of Speech-Language Pathology and Audiology, University of Pretoria, Gauteng, South Africa.
Purpose: This study aimed to describe the impact of a preschool hearing screening program in a low- and middle-income country (LMIC) in terms of referral outcomes and caregiver perspectives.
Method: This study included two components. First, a review of outcomes from a large-scale community-based hearing screening program, facilitated by community health workers (CHWs), for preschool children who failed their hearing screening.
Background: Emerging adulthood (typically ages 18-25) is a developmental period associated with increased likelihood of developing substance use disorders (SUDs) resulting in life-altering negative consequences. While SUD treatment can be effective and diminish substance-related consequences, very few emerging adults with SUDs actually receive treatment and research is needed to identify potential determinants of receiving care. We examined associations between individual factors and social determinants of health (SDOH) with SUD treatment service utilization to inform treatment engagement strategies for emerging adults.
View Article and Find Full Text PDFFeasibility and Acceptability of Formats in a Comparative Effectiveness Trial of a Preventive Parenting Program.
J Child Fam Stud
February 2025
Department of Psychology, Arizona State University, Tempe, AZ USA.
Parenting can be challenging, and military parents face additional family stressors related to relocations and deployments. ADAPT4U is an evidence-based preventive parenting program specifically designed for military parents of school-aged children. This study examines the feasibility and acceptability of in-person group and telehealth versions of the program.
View Article and Find Full Text PDFThree-dimensional analysis of mandibular and condylar growth using artificial intelligence tools: a comparison of twin-block and Frankel II Appliances.
BMC Oral Health
February 2025
Department of Orthodontics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Background: Analyzing the morphological growth changes upon mandibular advancement between Twin Block (TB) and Functional Regulator II (FR2) in Class II patients involves measuring the condylar and mandibular changes in terms of linear and volumetric measurements, as well as the distances registered after superimposition. Correspondingly, 3D digital assessment with the benefit of artificial intelligence tools was applied, and color-coded distance maps were descriptively interpreted to visualize the direction of growth.
Subjects And Methods: Twenty patients aged 9 to 12 years with skeletal Class II malocclusion with overjet (5-9 mm) were enrolled into two groups: Group 1 (TB) and Group 2 (FR2).
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