Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/1971110a0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Toxic Effects of Butanol in the Plane of the Cell Membrane.
Langmuir
January 2025
Department of Chemical and Environmental Engineering, University of Cincinnati, Cincinnati, Ohio 45220, United States.
Solvent toxicity limits -butanol fermentation titer, increasing the cost and energy consumption for subsequent separation processes and making biobased production more expensive and energy-intensive than petrochemical approaches. Amphiphilic solvents such as -butanol partition into the cell membrane of fermenting microorganisms, thinning the transverse structure, and eventually causing a loss of membrane potential and cell death. In this work, we demonstrate the deleterious effects of -butanol partitioning upon the lateral dimension of the membrane structure, called membrane domains or lipid rafts.
View Article and Find Full Text PDFSolvent induced method for preparation of multi-advantage carrageenan films.
Int J Biol Macromol
January 2025
Department of Pharmacy, Fujian Vocational College of Bioengineering, Fuzhou 350000, China. Electronic address:
Carrageenan has good film-forming characteristics, but it is difficult to simultaneously improve its multiple performances, such as water-resistance, light transmittance and thermal stability. In this study, multi-advantage composite films were prepared by iota-carrageenan and quaternary ammonium surfactants according to solvent induced method. The weight change, FTIR and thermogravimetric analyses of the films before and after solvent inducement indicated that the inorganic counterions of iota-carrageenan were replaced by quaternary ammonium ions.
View Article and Find Full Text PDFSupramolecular Assembly, Solvent-Induced, and Mechanochromic Luminescence of Au(I) Quinoline-8-thiolates.
Inorg Chem
December 2024
Department of Chemistry, National Taiwan University, 1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan.
AuCl(PMe) and AuCl(PEt) were used to react with quinoline-8-thiolate (8-QNS) to give three Au(I) complexes, i.e., [8-QNS(AuPMe)]ClO (), [(8-QNS)Ag(AuPMe)]ClO (), and [8-QNS(AuPEt)]ClO (), which have been structurally determined by X-ray diffraction to show various intra- and intermolecular metal···metal contacts (i.
View Article and Find Full Text PDFIntegral Solvent-Induced Protein Precipitation for Target-Engagement Studies in .
ACS Infect Dis
December 2024
OmicScouts GmbH, Lise-Meitner-Straße 30, D-85354 Freising, Germany.
The limited understanding of the mechanism of action (MoA) of several antimalarials and the rise of drug resistance toward existing malaria therapies emphasizes the need for new strategies to uncover the molecular target of compounds in . Integral solvent-induced protein precipitation (iSPP) is a quantitative mass spectrometry-based (LC-MS/MS) proteomics technique. The iSPP leverages the change in solvent-induced denaturation of the drug-bound protein relative to its unbound state, allowing identification of the direct drug-protein target without the need to modify the drug.
View Article and Find Full Text PDFStudying Target-Engagement of Anti-Infectives by Solvent-Induced Protein Precipitation and Quantitative Mass Spectrometry.
ACS Infect Dis
December 2024
OmicScouts GmbH, Lise-Meitner-Straße 30, Freising D-85354, Germany.
Antimicrobial resistance (AMR) poses a serious threat to global health. The rapid emergence of resistance contrasts with the slow pace of antimicrobial development, emphasizing the urgent need for innovative drug discovery approaches. This study addresses a critical bottleneck in early drug development by introducing integral solvent-induced protein precipitation (iSPP) to rapidly assess the target-engagement of lead compounds in extracts of pathogenic microorganisms under close-to-physiological conditions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!