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Objective: To investigate the similarities and differences of clinical manifestations and long-term prognosis between eosinophilic gastroenteritis (EGE) and eosinophilic granulomatosis with polyangiitis (EGPA) complicating GI involvement (EGPA-GI).

Methods: Sixty-two EGE and 30 EGPA-GI patients were retrospectively enrolled in PUMCH from 2008 to 2023. Baseline clinical records were collected.

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Intestinal parasites of the genus are the most prevalent in coproparasitological examinations and necropsies of dogs in Brazil. Although adult dogs often remain asymptomatic when infected, there is limited published information concerning the laboratory and clinical findings and severity of infection in symptomatic adult dogs. Therefore, this study aimed to characterize the clinical and laboratory findings of adult -infected dogs.

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Improvement in serum eosinophilia is observed in clinical responders to ustekinumab but not adalimumab in inflammatory bowel disease.

J Crohns Colitis

January 2025

Department of Medicine (Division of Gastroenterology) and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4K1, Canada.

Introduction: In inflammatory bowel disease (IBD), the number of eosinophils increases in the lamina propria of the intestinal tract, but their specific patho-mechanistic role remains unclear. Elevated blood eosinophil counts in active IBD suggest their potential as biomarkers for predicting response to biological therapies. This study evaluates blood eosinophil count trends and their predictive value for clinical response and endoscopic improvement in patients with IBD receiving ustekinumab or adalimumab induction therapy.

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Eosinophilic gastroenteritis is an uncommon, chronic, immune-mediated condition characterized by eosinophilic infiltration that can affect any segment of the gastrointestinal tract. Clinical manifestations depend on the different layers of the intestinal wall affected, which also allows its classification into three subtypes (Klein classification) (1): mucosal, which presents with abdominal pain, diarrhea, or vomiting; muscular, with obstruction or perforation; and serosal, classically with ascites. Diagnosis requires the demonstration of tissue eosinophilia with compatible clinical manifestations, after excluding other causes of eosinophilia.

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