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Clinical profile of an unselected population with heart failure treated with vericiguat in real life: differences with the VICTORIA trial.
Front Cardiovasc Med
January 2025
Cardiology Service, Hospital Universitario de La Princesa, Madrid, Spain.
Introduction: Vericiguat, an oral stimulator of soluble guanylate cyclase, reduces cardiovascular mortality and hospitalisations in patients with heart failure (HF) and reduced ejection fraction, as demonstrated in the VICTORIA trial. This study assessed the real-world use of vericiguat.
Material And Methods: This cross-sectional, prospective and multicenter registry (VERISEC) included 776 patients from 43 centres in Spain between December 2022 and October 2023.
Ultrasound-assisted immersion freezing improves the digestion properties of beef myofibrillar protein.
Food Chem X
January 2025
College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China.
This study focused on the effect of ultrasound-assisted immersion freezing (UIF) with different ultrasound power (200, 400, 600 W) on the physicochemical and digestive properties of beef myofibrillar proteins (BMP). The results showed that the solubility and thermal stability of BMP were significantly increased, when treated with 400 W ultrasound, and the α-helix, β-sheets, β-turns, and random-coil fractions structures content were higher and the fluorescence intensity was closest to that of the control group, demonstrating enhanced structural stability of BMP. The protein digestibility of the UIF-400 W group was significantly enhanced while the particle size of the digested product was reduced, which proved its enhanced digestion characteristics.
View Article and Find Full Text PDFPickering emulsion stabilized by hollow Zein/SSPS nanoparticles loaded with Thymol: Formation, characterization, and application in fruit preservation.
Food Res Int
February 2025
School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China. Electronic address:
Using Pickering emulsion (PE) as the carrier of active compounds in bio-based coatings constitutes a highly promising research domain. This study focused on creating a food-grade, biocompatible, and antibacterial PE to coat fresh fruits and vegetables, extending their shelf life. Hollow zein/soluble soybean polysaccharide nanoparticles loaded with thymol (H-ZSH/T) were produced using NaHCO as a sacrificial template to stabilize PE.
View Article and Find Full Text PDFA method for facile production of variable lymphocyte receptors using SHuffle Escherichia coli.
Biotechnol Prog
January 2025
Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Variable lymphocyte receptors (VLRs) are the antigen receptors of jawless vertebrates such as lamprey. VLRs are of growing biotechnological interest for their ability to bind certain antigenic targets with higher affinity than traditional immunoglobulins. However, VLRs are disulfide-bonded proteins that are often challenging to produce requiring genetic modifications, fusion partners, non-scalable host cell lines or inclusion body formation and refolding.
View Article and Find Full Text PDFGlufosinate (GLUF) and glyphosate (GLY) are nonselective phosphorus-containing amino acid herbicides that are widely used in agricultural gardens and noncultivated areas. These herbicides give rise to a number of key metabolites, with 3-methyl phosphinicopropionic acid (MPPA), -acetyl glufosinate (-acetyl GLUF), aminomethyl phosphonic acid (AMPA), -acetyl aminomethyl phosphonic acid (-acetyl AMPA), -acetyl glyphosate (-acetyl GLY), -methyl glyphosate (-methyl GLY) as the major metabolites obtained from GLUF and GLY. Extensive use of these herbicides may lead to their increased presence in the environment, especially aquatic ecosystems.
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