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Lymphotoxin beta-activated LTBR/NIK/RELB axis drives proliferation in cholangiocarcinoma.
Liver Int
November 2024
Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg University Hospital, Heidelberg, Germany.
Background And Aims: Cholangiocarcinoma (CCA) is an aggressive malignancy arising from the intrahepatic (iCCA) or extrahepatic (eCCA) bile ducts with poor prognosis and limited treatment options. Prior evidence highlighted a significant contribution of the non-canonical NF-κB signalling pathway in initiation and aggressiveness of different tumour types. Lymphotoxin-β (LTβ) stimulates the NF-κB-inducing kinase (NIK), resulting in the activation of the transcription factor RelB.
View Article and Find Full Text PDFEtiology-independent activation of the LTβ-LTβR-RELB axis drives aggressiveness and predicts poor prognosis in HCC.
Hepatology
August 2024
Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, University Hospital Heidelberg, Heidelberg, Germany.
Background And Aims: HCC is the most common primary liver tumor, with an increasing incidence worldwide. HCC is a heterogeneous malignancy and usually develops in a chronically injured liver. The NF-κB signaling network consists of a canonical and a noncanonical branch.
View Article and Find Full Text PDFThree-dimensional nuclear architecture distinguishes thyroid cancer histotypes.
Int J Cancer
November 2023
CancerCare Manitoba Research Institute, CancerCare Manitoba, University of Manitoba, Winnipeg, Canada.
Molecular markers can serve as diagnostic tools to support pathological analysis in thyroid neoplasms. However, because the same markers can be observed in some benign thyroid lesions, additional approaches are necessary to differentiate thyroid tumor subtypes, prevent overtreatment and tailor specific clinical management. This applies particularly to the recently described variant of thyroid cancer referred to as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP).
View Article and Find Full Text PDFSpecific recognition of an fusion by tumor infiltrating lymphocytes from a patient with metastatic cholangiocarcinoma.
J Immunother Cancer
April 2023
Surgery Branch, National Cancer Institute, Bethesda, Maryland, USA
Background: Metastatic cholangiocarcinoma (CC), a form of gastrointestinal cancer that originates from the bile ducts, cannot be cured by currently available therapies, and is associated with dismal prognosis. In a previous case report, adoptive transfer of autologous tumor infiltrating lymphocytes (TILs), the majority of which recognized a tumor-specific point mutation, led to a profound and durable cancer regression in a patient with metastatic CC. Thus, more effective treatment for patients with this disease may be developed by using TILs that target cancer-specific mutations, but also other genetic aberrations such as gene fusions.
View Article and Find Full Text PDFComputed tomography can differentiate vaginal-origin from uterine-origin lesions in bitches.
Am J Vet Res
November 2022
Department of Veterinary Medical Imaging, College of Veterinary Medicine, Seoul National University, Seoul, South Korea.
Objective: To investigate typical computed tomography (CT) features for the differentiation of vaginal from the uterine origin in dogs.
Animals: 7 healthy Beagles in the prospective study and 5 bitches in the retrospective study.
Procedures: In the prospective study, dual-phase CT images were obtained from sexually intact female Beagles (n = 7) during anestrus and estrus.
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