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The 5-HT7 receptor contributes to increased hindquarter blood flow caused by skeletal muscle contraction.
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Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824-1317 USA.
Serotonin (5-hydroxytryptamine, 5-HT) at low plasma concentrations reduces blood pressure and dilates some skeletal muscle arterioles in the rat. We hypothesized that the 5-HT7 receptor is essential for both 5-HT-induced changes in blood pressure and skeletal muscle arteriolar function. Male 5-HT7 receptor knock out (KO) rats under isoflurane anesthesia had a higher resting hindquarter vascular resistance [HQVR; mm Hg/ml/min; KO (16.
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J Headache Pain
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School of Medicine, Nankai University, Tianjin, 300071, China.
Background: Migraine is the second disabling neurological disorder with a high prevalence. Aura occurs in one-third of migraineurs and visual aura accounts for over 90%. Cortical spreading depression (CSD) underlies aura and might trigger migraine headaches.
View Article and Find Full Text PDFMelatonin for preventing postoperative delirium in elderly patients: A multicenter randomized placebo-controlled pilot study.
Medicine (Baltimore)
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Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada.
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View Article and Find Full Text PDFA current review on animal models of anti-asthmatic drugs screening.
Front Pharmacol
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Department of Pharmacology, Nims Institute of Pharmacy, Nims University Rajasthan, Jaipur, Rajasthan, India.
Asthma is a chronic inflammatory respiratory condition characterised by airway constriction, smooth muscle spasm, and severe morbidity. It affects around 300 million people globally, with children being especially vulnerable. Despite its worldwide effect, the invention of innovative asthma medicines has been slow over the last 5 decades, leaving significant unmet requirements in asthma care.
View Article and Find Full Text PDFAnaesthetic implications of psilocybin and lysergic acid diethylamide: what is old is now new: A narrative review on psychedelics and anaesthesia.
Eur J Anaesthesiol
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From the Queen's School of Medicine, Kingston (MD), Queen's Department of Psychology (RS) and Kingston Health Sciences Centre, Kingston, Ontario, Canada (TC, CH, DC).
Psychedelic drugs, known for their perception-altering properties, are gaining popularity in the treatment of mental health and pain disorders. As exploratory studies demonstrate clinical efficacy with few adverse events, it is expected that more patients will ingest psychedelic drugs. For therapeutic reasons, as with any drug, anaesthesiologists must be aware of its physiological effects and contraindications to ensure the safe provision of anaesthesia.
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