Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/00221325.1962.10533590 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Disruptions in Reward-Guided Decision-Making Functions Are Predictive of Greater Oral Oxycodone Self-Administration in Male and Female Rats.
Biol Psychiatry Glob Open Sci
May 2025
Department of Neuroscience, University of Minnesota, Twin Cities, Minneapolis, Minnesota.
Background: Problematic opioid use that emerges in a subset of individuals may be due to preexisting disruptions in the biobehavioral mechanisms that regulate drug use. The identity of these mechanisms is not known, but emerging evidence suggests that suboptimal decision making that is observable prior to drug use may contribute to the pathology of addiction.
Methods: The current study investigated the relationship between decision-making phenotypes and opioid-taking behaviors in male and female Long Evans rats.
Role of the neuropeptide S receptor 1 rs324981 polymorphism in modulating emotionality and cognitive flexibility: Insights from a gene-edited mouse model.
Behav Brain Res
March 2025
Department of Behavioural Biology, Osnabrück University, Osnabrück, Germany. Electronic address:
The neuropeptide S (NPS) and its receptor (NPSR1) are involved in various physiological processes, including arousal, sleep, anxiety, memory, and stress responses in rodents. Recent attention has focused on the association between the NPS/NPSR1 system and stress-related disorders, particularly involving a specific single nucleotide polymorphism (SNP) in the NPSR1 gene (rs324981). This SNP causes an amino acid change at position 107 in the protein, reducing NPSR1 signalling potency; however, its effects on behavioural, cognitive, and physiological aspects relevant to stress-related disorders remain unclear.
View Article and Find Full Text PDFComputational modeling of reversal learning impairments in schizophrenia and bipolar disorder reveals shared failure to exploit rewards.
J Psychopathol Clin Sci
March 2025
Department of Psychiatry, University of Rochester.
The distinction between the concepts of schizophrenia and bipolar disorder is fundamental to the Kraepelinian tradition in psychiatry. One mechanism undergirding this distinction, a difference in reward sensitivity, has been championed by a number of scholars. As part of the Cognitive Neuroscience Test Reliability and Clinical applications for Serious mental illnesses consortium, 225 participants including people with schizophrenia ( = 69), schizoaffective disorder ( = 55), and bipolar affective disorder ( = 53) performed a probabilistic reversal learning task.
View Article and Find Full Text PDFAccurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects by RaMBat.
bioRxiv
February 2025
Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA.
As the most common malignant pediatric brain cancer, medulloblastoma (MB) accounts for around 20% of all pediatric central nervous system (CNS) neoplasms. MB includes a complex array of distinct molecular subtypes, mainly including SHH, WNT, Group 3 and Group 4. Accurate identification of MB subtypes enables improved downstream risk stratification and tailored therapeutic treatment design.
View Article and Find Full Text PDFAlterations in the Glymphatic System and Presence of Small Vessel Disease in Hospitalized and Non-hospitalized COVID Patients: A Study of PSMD Index and DTI-ALPS.
Acad Radiol
March 2025
Ondokuz Mayis University, Faculty of Medicine, Department of Neuroradiology, Samsun, Turkey (B.G., A.K.).
Background: It is known that COVID-19 causes brain damage in the acute phase and leads to neurological complications such as dementia and brain fog in the chronic phase. Many factors have been implicated in these complications, including glymphatic system disorders, small vessel disease, and widespread inflammation. Peak width of skeletonized mean diffusivity (PSMD) is a sensitive biomarker for SVD, while the diffusion tensor image analysis along the perivascular space (DTI-ALPS) measures glymphatic system function.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!