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Bloodstream infection in a neonatal intensive care unit: Epidemiology, Antifungal susceptibility and new drug delivered strategies.
J Mycol Med
January 2025
Mycology Laboratory, School of Pharmacy, Midwestern Paraná State University, UNICENTRO, PR, Brazil. Electronic address:
Bloodstream infection in neonates is a complicated disease and presents a major challenge both in diagnosis and in therapeutic intervention. The focus of the present study was to investigate the incidence, the species distribution and the risk factors associated with mortality of bloodstream infections in a neonatal intensive care unit (NICU) and evaluating the antifungal susceptibility of traditional antifungal drugs and three nanoparticle-based drug delivery systems based on nanoparticles. A total of 458 patients were evaluated, and 9.
View Article and Find Full Text PDFAP39, a novel mitochondria-targeted hydrogen sulfide donor, promotes cutaneous wound healing in an in vivo murine model of acute frostbite injury.
Biomed Pharmacother
January 2025
Department of Surgery, Division of Urology, London Health Sciences Center, Western University, London, Ontario, Canada; Matthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, Western University, London, Ontario, Canada; Multi-Organ Transplant Program, London Health Sciences Center, Western University, London, Ontario, Canada; Department of Microbiology & Immunology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada. Electronic address:
Frostbite injury refers to cold tissue injury which typically affects the peripheral areas of the body, and is associated with limb loss and high rates of morbidity. Historically, treatment options have been limited to supportive care, leading to suboptimal outcomes for affected patients. The pathophysiology of frostbite injury has been understood in recent years to share similarity with that of cold ischemia-reperfusion injury as seen in solid organ transplantation, of which mitochondria play an important contributing role.
View Article and Find Full Text PDFEnhancing immunotherapy efficacy with synergistic low-dose radiation in metastatic melanoma: current insights and prospects.
J Exp Clin Cancer Res
January 2025
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Recent advances in oncology research have highlighted the promising synergy between low-dose radiation therapy (LDRT) and immunotherapies, with growing evidence highlighting the unique benefits of the combination. LDRT has emerged as a potent tool for stimulating the immune system, triggering systemic antitumor effects by remodeling the tumor microenvironment. Notably, LDRT demonstrates remarkable efficacy even in challenging metastatic sites such as the liver (uveal) and brain (cutaneous), particularly in advanced melanoma stages.
View Article and Find Full Text PDF[The Effects of Temoporfin-Mediated Photodynamic Inactivation on Leishmania tropica Promastigotes and Molecular Docking Analysis].
Mikrobiyol Bul
January 2025
Uşak Üniversitesi Tıp Fakültesi, Biyofizik Anabilim Dalı, Uşak.
Layşmanyaz, yaklaşık 90'dan fazla ülke ve bölgeden bildirilen, ciddi ve endemik bir bulaşıcı hastalıktır. Kutanöz layşmanyaz (KL) ise vücudun açıkta kalan bölgelerinde oluşan, başlıca semptomları arasında vektör Phlebotomus ısırığından altı ay sonra kronikleşebilen veya kendiliğinden iyileşebilen ciltte tek, birden fazla ülserli veya nodüler lezyonlar bulunan, ölümcül olmayan ancak kalıcı izler bırakabilen bir hastalıktır. Klasik tedavi yöntemleri, uygulamada zorluk, direnç gelişimi ve yan etki gibi bir dizi soruna neden olmaktadır.
View Article and Find Full Text PDFTreatment of Cutaneous Adnexal Carcinoma With Radiotherapy: A 20-Year, Single-Institution Experience in 49 Patients.
Am J Clin Oncol
January 2025
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.
Objectives: Cutaneous adnexal carcinomas (CACs) are rare skin cancers with no established treatment guidelines. Given the limited data, this study aims to explore the characteristics and outcomes of patients with CAC treated with radiation therapy (RT).
Methods: Patients diagnosed with CAC between 2000 and 2020 who received RT were included.
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