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A novel ENTH domain-containing protein TgTEPSIN is essential for structural maintenance of the plant-like vacuolar compartment and bradyzoite differentiation in toxoplasma gondii.
Int J Biol Macromol
January 2025
National Animal Protozoa Laboratory and School of Veterinary Medicine, China Agricultural University, Beijing 100193, China; Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, and Laboratory of Zoonotic Diseases, School of Public Health (Shenzhen), Sun Yat-Sen University, Shenzhen Campus, Shenzhen 518107, China. Electronic address:
Toxoplasma gondii is an intracellular and parasitic protozoon that harbors specialized cellular structures and molecular mechanisms, including the Plant-like Vacuolar Compartment (PLVAC). The PLVAC performs multifaceted roles in the parasite, contributing to ion homeostasis, proteolysis, pH regulation, and autophagy. Despite significant efforts over the past decade to characterize the PLVAC, the proteins localized to this organelle remain largely unidentified.
View Article and Find Full Text PDFPlasmodium falciparum raf kinase inhibitor is a lipid binding protein that interacts with and regulates the activity of PfCDPK1, an essential plant-like kinase required for red blood cell invasion.
Biochem Biophys Res Commun
January 2025
Molecular Parasitology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India. Electronic address:
Raf Kinase Inhibitor Protein (RKIP) is an important regulator of the MAPK signaling pathway in multicellular eukaryotes. Plasmodium falciparum RKIP (PfRKIP) is a putative phosphatidylethanolamine binding protein (PEBP) that shares limited similarity with Homo sapiens RKIP (HsRKIP). Interestingly, critical components of the MAPK pathway are not expressed in malaria parasites and the physiological function of PfRKIP remains unknown.
View Article and Find Full Text PDFAltering Carotene Hydroxylase Activity of DcCYP97C1 Affects Carotenoid Flux and Changes Taproot Colour in Carrot.
Plant Cell Environ
December 2024
State Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Ministry of Agriculture and Rural Affairs Key Laboratory of Biology and Germplasm Enhancement of Horticultural Crops in East China, College of Horticulture, Nanjing Agricultural University, Nanjing, China.
CYP97C1 as a haem-containing cytochrome P450 hydroxylase (P450-type) is important for carotene hydroxylation and xanthophyll biosynthesis. Research about this type of hydroxylase was mainly reported in several model plant species which have no specialized tissues accumulating massive carotenoids. The function of CYP97C1 in the horticultural plant, like carrots, was not fully studied.
View Article and Find Full Text PDFUnderstanding the Development of Compensatory Pathways in a Mutant Malaria Parasite Harbouring Hypomorphic Allele of Plant-Like Kinases.
J Vis Exp
November 2024
Cellular and Molecular Parasitology Laboratory, School of Life Sciences, Jawaharlal Nehru University; Laboratory of Malaria and Vector Research and National Institutes of Allergy and Infectious Diseases, National Institutes of Health;
Article Synopsis
- The malaria parasite can alter its transcriptome to resist the effects of drugs, particularly affecting multigene families.
- CDPK family protein kinases in Plasmodium falciparum are crucial for its development and are potential targets for anti-malarial drugs.
- By using a chemical genetics approach to study a mutant parasite with a modified cdpk1 gene, researchers aim to discover compensatory mechanisms that could be targeted to combat drug resistance.
Engineering CO-fixing modules in E. coli via efficient assembly of cyanobacterial Rubisco and carboxysomes.
Plant Commun
December 2024
Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7ZB, United Kingdom; MOE Key Laboratory of Evolution and Marine Biodiversity, Frontiers Science Center for Deep Ocean Multispheres and Earth System & College of Marine Life Sciences, Ocean University of China, Qingdao, 266003, China. Electronic address:
Rubisco (ribulose 1,5-bisphosphate carboxylase/oxygenase) is the central enzyme for converting atmospheric CO into organic molecules, playing a crucial role in the global carbon cycle. In cyanobacteria and some chemoautotrophs, Rubisco complexes, along with carbonic anhydrase, are enclosed within specific proteinaceous microcompartments, known as carboxysomes. The polyhedral carboxysome shell ensures a dense packaging of Rubisco and creates a high-CO internal environment to facilitate the fixation of CO.
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