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Effect of Trichomonacide 6-Nitro-1-benzimidazole Derivative Compounds on Expression Level of Metabolic Genes in .
Int J Mol Sci
April 2024
Laboratorio de Inmunoquímica, Hospital Infantil de México Federico Gómez, Secretaría de Salud, Mexico City 06720, Mexico.
The parasite is the etiologic agent of trichomoniasis, the most common non-viral sexually transmitted disease worldwide. This infection often remains asymptomatic and is related to several health complications. The traditional treatment for trichomoniasis is the use of drugs of the 5-nitroimidazole family, such as metronidazole; however, scientific reports indicate an increasing number of drug-resistant strains.
View Article and Find Full Text PDFMetabolomics analysis reveals changes related to pseudocyst formation induced by iron depletion in Trichomonas vaginalis.
Parasit Vectors
July 2023
Department of Parasitology, College of Medicine, Chang Gung University, Guishan Dist., Taoyuan City, Taiwan.
Background: Iron is an essential element for cellular functions, such as energy metabolism. Trichomonas vaginalis, a human urogenital tract pathogen, is capable of surviving in the environment without sufficient iron supplementation. Pseudocysts (cyst-like structures) are an environmentally tolerated stage of this parasite while encountering undesired conditions, including iron deficiency.
View Article and Find Full Text PDFRecent Advances in the Development of Triose Phosphate Isomerase Inhibitors as Antiprotozoal Agents.
Curr Med Chem
May 2022
Laboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, 88710 Reynosa, México.
Article Synopsis
- * The glycolysis pathway, particularly the enzyme triose phosphate isomerase (TIM), is highlighted as a potential target for developing antiprotozoal agents because of structural differences between protozoan TIM and human TIM, allowing for selective inhibitors.
- * The review covers various drug design strategies and successful TIM inhibitors with specific chemical structures that interact with the enzyme to impede its activity, showcasing their potential in treating diseases such as Chagas disease and malaria.
The Road Less Traveled? Unconventional Protein Secretion at Parasite-Host Interfaces.
Front Cell Dev Biol
May 2021
Institute of Cell Biology, University of Bern, Bern, Switzerland.
Protein secretion in eukaryotic cells is a well-studied process, which has been known for decades and is dealt with by any standard cell biology textbook. However, over the past 20 years, several studies led to the realization that protein secretion as a process might not be as uniform among different cargos as once thought. While in classic canonical secretion proteins carry a signal sequence, the secretory or surface proteome of several organisms demonstrated a lack of such signals in several secreted proteins.
View Article and Find Full Text PDFProtein cysteine S-nitrosylation provides reducing power by enhancing lactate dehydrogenase activity in Trichomonas vaginalis under iron deficiency.
Parasit Vectors
September 2020
Department of Parasitology, College of Medicine, Chang Gung University, Guishan District, Taoyuan City, Taiwan.
Background: Iron plays essential roles in the pathogenesis and proliferation of Trichomonas vaginalis, the causative agent of the most prevalent non-viral human sexually transmitted infection. We previously demonstrated that under iron deficiency, the endogenous nitric oxide (NO) is accumulated and capable of regulating the survival of T. vaginalis.
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